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5/20/2015 5:01:00 PM | Browse: 904 | Download: 926
Publication Name World Journal of Gastroenterology
Manuscript ID 14246
Country/Territory Italy
Received
2014-09-26 08:52
Peer-Review Started
2014-09-29 09:30
To Make the First Decision
2014-12-02 09:25
Return for Revision
2014-12-03 10:49
Revised
2014-12-20 07:10
Second Decision
2015-03-11 15:22
Accepted by Journal Editor-in-Chief
2015-03-11 15:33
Accepted by Company Editor-in-Chief
2015-03-19 17:05
Articles in Press
2015-03-19 17:44
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-05-05 17:22
Publish the Manuscript Online
2015-05-20 17:01
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Prospective Study
Article Title Vascular endothelial growth factor and tryptase changes after chemoembolization in hepatocarcinoma patients
Manuscript Source Invited Manuscript
All Author List Girolamo Ranieri, Michele Ammendola, Ilaria Marech, Annamaria Laterza, Ines Abbate, Caroline Oakley, Angelo Vacca, Rosario Sacco and Cosmo Damiano Gadaleta
Funding Agency and Grant Number
Funding Agency Grant Number
Alleanza Contro il Cancro” project), the Italian National Health Institute and the Italian Ministry of Health(partly).
Corresponding Author Girolamo Ranieri, MD, Diagnostic and Interventional Radiology Unit with Integrated Section of Translational Medical Oncology, National Cancer Research Centre, Istituto Tumori “Giovanni Paolo II”, Via Orazio Flacco 65, 70124 Bari, Italy. giroran@tiscalinet.it
Key Words Serum levels; Trypatse; Vascular Endothelial Growth Factor; Hepatocellular Cancer; Chemoembolization
Core Tip Experimental data suggest that vascular endothelial growth factor (VEGF) and tryptase play a role in tumour angiogenesis. This study aims to assess VEGF and tryptase serum concentrations from 71 hepatocellular cancer patients before and after hepatic trans-arterial chemoembolization (TACE) by mean of enzyme-linked immuno-absorbent assay and fluoro-enzyme immunoassay methods respectively. Here, we demonstrated higher serum VEGF levels and lower tryptase levels following TACE as compared to pre-TACE levels. We suggest that changes of VEGF and tryptase levels may be biomarkers of response to therapy. In this context tryptase and VEGF receptor axis inhibitors may be evaluated as adjuvant therapies.
Publish Date 2015-05-20 17:01
Citation Ranieri G, Ammendola M, Marech I, Laterza A, Abbate I, Oakley C, Vacca A, Sacco R, Gadaleta CD. Vascular endothelial growth factor and tryptase changes after chemoembolization in hepatocarcinoma patients. World J Gastroenterol 2015; 21(19): 6018-6025
URL http://www.wjgnet.com/1007-9327/full/v21/i19/6018.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i19.6018
Full Article (PDF) WJG-21-6018.pdf
Full Article (Word) WJG-21-6018.doc
Manuscript File 14246-Review.doc
Answering Reviewers 14246-Answering reviewers.pdf
Copyright License Agreement 14246-Copyright assignment.pdf
Peer-review Report 14246-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 14246-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 14246-Scientific misconduct check.pdf
Scientific Editor Work List 14246-Scientific editor work list.pdf