Publication Name	World Journal of Psychiatry
Manuscript ID	14351
Country	United States

Received	2014-09-29 11:58
Peer-Review Started	2014-09-29 15:55
To Make the First Decision	2014-10-28 14:35
Return for Revision	2014-10-30 17:46
Revised	2014-11-27 04:26
Second Decision	2015-01-04 16:00
Accepted by Journal Editor-in-Chief	2015-01-05 06:37
Accepted by Company Editor-in-Chief	2015-01-12 14:34
Articles in Press	2015-01-12 14:34
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-03-12 11:06
Publish the Manuscript Online	2015-03-23 14:43

ISSN	2220-3206 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Psychiatry
Manuscript Type	Review
Article Title	Smoking in schizophrenic patients: A critique of the self-medication hypothesis
Manuscript Source	Invited Manuscript
All Author List	Francesca Manzella, Susan E Maloney and George T Taylor
Funding Agency and Grant Number	Funding Agency Grant Number University of Missouri System(In part) UM-Research Board and the Interdisciplinary Intercampus Research Program to GTT W.M. Keck Foundation to SEM
Corresponding Author	Susan E Maloney, PhD, Department of Genetics, Washington University School of Medicine, 4655 Scott Ave, Campus Box 8232, St. Louis, MO 63110, United States. maloneys@psychiatry.wustl.edu
Key Words	Nicotine; Nicotinic receptor; Dopamine; Positive-negative symptoms; Side effects; Age of onset; Smoking cessation
Core Tip	The high rates of smoking in mentally ill people have led to the uncritical acceptance that these individuals smoke to self-medicate with nicotine. A self-medication hypothesis (SMH) proposed three decades ago set the stage for explanations for smoking associated with mental illness. Here, we review the origins of the SMH and apply stated and implied predictions to smoking in patients. Our conclusions are that there is some support for the SMH explanations for smoking in schizophrenic patients. However, there are sufficient contradictory data, and predictions not adequately tested, to justify continued empirical studies and new alternative hypotheses to the self-medication concept.
Publish Date	2015-03-23 14:43
Citation	Manzella F, Maloney SE, Taylor GT. Smoking in schizophrenic patients: A critique of the self-medication hypothesis. World J Psychiatr 2015; 5(1): 35-46
URL	http://www.wjgnet.com/2220-3206/full/v5/i1/35.htm
DOI	http://dx.doi.org/10.5498/wjp.v5.i1.35

Full Article (PDF)	WJP-5-35.pdf
Full Article (Word)	WJP-5-35.doc
Manuscript File	14351-Review.docx
Answering Reviewers	14351-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	14351-Conflict-of-interest statement.pdf
Copyright License Agreement	14351-Copyright assignment.pdf
Peer-review Report	14351-Peer review(s).pdf
Scientific Misconduct Check	14351-CrossCheck.jpg
Scientific Editor Work List	14351-Scientific editor work list.pdf