Publication Name	World Journal of Critical Care Medicine
Manuscript ID	14500
Country

Received	2014-10-08 08:47
Peer-Review Started	2014-10-08 18:02
To Make the First Decision	2014-11-14 19:49
Return for Revision	2014-11-19 17:12
Revised	2014-11-21 15:07
Second Decision	2014-12-11 17:25
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-12-17 16:13
Articles in Press	2014-12-17 16:14
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-02-05 17:48
Publish the Manuscript Online	2015-02-11 18:50

ISSN	2220-3141(online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Infectious Diseases
Manuscript Type	Review
Article Title	Antibiotic stewardship programmes in intensive care units: Why, how, and where are they leading us
Manuscript Source	Invited Manuscript
All Author List	Yu-Zhi Zhang and Suveer Singh
Funding Agency and Grant Number
Corresponding Author	Dr. Suveer Singh, BSc, MBBS, PhD, EDIC, DICM, FFICM, FRCP, Departments of Intensive Care and Respiratory Medicine, Chelsea and Westminster Hospital, 369 Fulham Rd, London SW10 9NH, United Kingdom. suveer.singh@imperial.ac.uk
Key Words	Antibiotic stewardship programme; Intensive care; Antimicrobial resistance; Antibacterial resistance; Antibiotic resistance
Core Tip	Antibiotic stewardship programmes (ASPs) aim to optimise appropriate antibiotic treatment and minimise antimicrobial resistance (AMR). Multistrategic approaches must address challenges to future management of infectious disease. Models of ASP in intensive care unit, include “standard” control of antibiotic prescribing (e.g.,”de-escalation strategies”) through to interventional approaches utilising biomarker-guided decisions. Protocolised ASPs using procalcitonin guided antibiotic-stop but not antibiotic-start alone decisions demonstrate reduced antibiotic and AMR rates, but not survival benefit. Immediate research needs include better AMR surveillance, early microbial diagnostic tests, and core transferable elements of ASPs.
Publish Date	2015-02-11 18:50
Citation	Zhang YZ, Singh S. Antibiotic stewardship programmes in intensive care units: Why, how, and where are they leading us? World J Crit Care Med 2015; 4(1): 13-28
URL	http://www.wjgnet.com/2220-3141/full/v4/i1/13.htm
DOI	http://dx.doi.org/10.5492/wjccm.v4.i1.13

Full Article (PDF)	WJCCM-4-13.pdf
Full Article (Word)	WJCCM-4-13.doc
Manuscript File	14500-Review.doc
Answering Reviewers	14500-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	14500-Conflict-of-interest statement.pdf
Copyright License Agreement	14500-Copyright assignment.pdf
Peer-review Report	14500-Peer review(s).pdf
Scientific Misconduct Check	14500-CrossCheck.jpg
Scientific Editor Work List	14500-Scientific editor work list.pdf