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4/27/2015 4:29:00 PM | Browse: 576 | Download: 1026
Publication Name World Journal of Gastroenterology
Manuscript ID 14518
Country/Territory China
2014-10-11 13:32
Peer-Review Started
2014-10-11 14:48
To Make the First Decision
2014-10-29 15:02
Return for Revision
2014-11-03 10:22
2014-11-24 21:49
Second Decision
2014-12-04 14:44
Accepted by Journal Editor-in-Chief
2014-12-05 03:30
Accepted by Company Editor-in-Chief
2014-12-16 10:06
Articles in Press
2014-12-16 10:39
Publication Fee Transferred
Edit the Manuscript by Language Editor
2015-01-12 11:27
Typeset the Manuscript
2015-04-13 16:10
Publish the Manuscript Online
2015-04-27 16:22
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Basic Study
Article Title Inflammatory microenvironment and expression of chemokines in hepatocellular carcinoma
Manuscript Source Unsolicited Manuscript
All Author List Ke-Qi Han, Xue-Qun He, Meng-Yu Ma, Xiao-Dong Guo, Xue-Min Zhang, Jie Chen, Hui Han, Wei-Wei Zhang, Quan-Gang Zhu, Hua Nian and Li-Jun Ma
Funding Agency and Grant Number
Funding Agency Grant Number
Natural Science Foundation of China 81072954
Corresponding Author Dr. Li-Jun Ma, Department of Oncology, Tongren Hospital of Shanghai Jiaotong University School of Medicine, 1111 Xianxia Road, Shanghai 200336, China. ljma5@hotmail.com
Key Words Chemokines; Gene expression profile; Hepatocellular carcinoma; PCR array; RNA interference
Core Tip An orthotopic transplantation tumor model of hepatocellular carcinoma (HCC) with CBRH-7919 cells was established. Inflammatory cell infiltration and macrophage phenotype were assessed by immunohistochemistry. A chemokine PCR array was used to identify differentially expressed genes, and tumor growth was assessed after knockdown with RNA interference. This study describes the inflammatory microenvironment and differential expression of chemokines in hepatocellular carcinoma. The data suggest that CXCL1 plays a critical role in tumor growth and may serve as a potential molecular target for use in HCC therapy.
Publish Date 2015-04-27 16:22
Citation Han KQ, He XQ, Ma MY, Guo XD, Zhang XM, Chen J, Han H, Zhang WW, Zhu QG, Nian H, Ma LJ. Inflammatory microenvironment and expression of chemokines in hepatocellular carcinoma. World J Gastroenterol 2015; 21(16): 4864-4874
Url http://www.wjgnet.com/1007-9327/full/v21/i16/4864.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i16.4864
Full Article (PDF) WJG-21-4864.pdf
Full Article (Word) WJG-21-4864.doc
Manuscript File 14518-Review.doc
Answering Reviewers 14518-Answering reviewers.pdf
Biostatistics Review Certificate 14518-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 14518-Conflict-of-interest.pdf
Copyright License Agreement 14518-Copyright assignment.pdf
Data Sharing Statement 14518-Data sharing statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document 14518-Institutional Animal Care and Use Committee Statement.pdf
Institutional Review Board Approval Form or Document 14518-Institutional Review Board statement.pdf
Non-Native Speakers of English Editing Certificate 14518-Language certificate.pdf
Peer-review Report 14518-Peer review(s).pdf
Scientific Misconduct Check 14518-CorssCheck.jpg
Scientific Editor Work List 14518-Scientific editor work list.pdf