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Articles Published Processes
5/30/2015 1:35:00 PM | Browse: 1062 | Download: 2181
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Received |
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2014-10-13 08:48 |
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Peer-Review Started |
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2014-10-13 20:47 |
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To Make the First Decision |
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2014-11-14 18:53 |
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Return for Revision |
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2014-11-20 09:14 |
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Revised |
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2014-12-12 15:16 |
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Second Decision |
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2015-02-04 08:04 |
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Accepted by Journal Editor-in-Chief |
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2015-02-04 08:24 |
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Accepted by Executive Editor-in-Chief |
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2015-02-12 21:18 |
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Articles in Press |
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2015-02-13 11:23 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2015-03-05 10:41 |
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Typeset the Manuscript |
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2015-05-13 17:31 |
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Publish the Manuscript Online |
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2015-05-30 13:32 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
SGK1 inhibits cellular apoptosis and promotes proliferation via the MEK/ERK/p53 pathway in colitis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jian-An Bai, Gui-Fang Xu, Li-Jun Yan, Wei-Wen Zeng, Qian-Qian Ji, Jin-Dao Wu and Qi-Yun Tang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81470806 |
| National Natural Science Foundation of Jiangsu Province |
BK20141496 |
| Public Health Ministry of Jiangsu Province in the Talents in Medical Science Program |
RC201179 |
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| Corresponding Author |
Qi-Yun Tang, MD, PhD, Department of Gastroenterology, First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Rd, Nanjing 210029, China. tqy831@163.com |
| Key Words |
Colitis; Serum-and-glucocorticoid-inducible-kinase-1; MEK/ERK; Apoptosis; p53 |
| Core Tip |
This study showed that serum-and-glucocorticoid-inducible-kinase-1 (SGK1) expression was significantly increased in the inflamed epithelia of patients with active Crohn’s disease (CD) in a TNBS-induced colitis model. At the cellular level, silencing of SGK1 inhibited the phosphorylation of mitogen-activated protein kinase kinase 1 (MEK1) and the downstream molecule ERK1/2, which induced the upregulation of p53 and Bcl-2-associated X protein, triggering subsequent cellular apoptosis and inhibition of proliferation in intestinal epithelial cells. A MEK1 inhibitor (i.e., U0126) was used to show that this was a MEK/ERK-dependent process. Co-immunoprecipitation analysis uncovered the mechanism of the interaction between SGK1 and MEK1. Our results provide a new therapeutic approach to CD therapy. |
| Publish Date |
2015-05-30 13:32 |
| Citation |
Bai JA, Xu GF, Yan LJ, Zeng WW, Ji QQ, Wu JD, Tang QY. SGK1 inhibits cellular apoptosis and promotes proliferation via the MEK/ERK/p53 pathway in colitis. World J Gastroenterol 2015; 21(20): 6180-6193 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i20/6180.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i20.6180 |
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