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5/30/2015 1:35:00 PM | Browse: 979 | Download: 1897
Publication Name World Journal of Gastroenterology
Manuscript ID 14561
Country/Territory China
Received
2014-10-13 08:48
Peer-Review Started
2014-10-13 20:47
To Make the First Decision
2014-11-14 18:53
Return for Revision
2014-11-20 09:14
Revised
2014-12-12 15:16
Second Decision
2015-02-04 08:04
Accepted by Journal Editor-in-Chief
2015-02-04 08:24
Accepted by Company Editor-in-Chief
2015-02-12 21:18
Articles in Press
2015-02-13 11:23
Publication Fee Transferred
Edit the Manuscript by Language Editor
2015-03-05 10:41
Typeset the Manuscript
2015-05-13 17:31
Publish the Manuscript Online
2015-05-30 13:32
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title SGK1 inhibits cellular apoptosis and promotes proliferation via the MEK/ERK/p53 pathway in colitis
Manuscript Source Unsolicited Manuscript
All Author List Jian-An Bai, Gui-Fang Xu, Li-Jun Yan, Wei-Wen Zeng, Qian-Qian Ji, Jin-Dao Wu and Qi-Yun Tang
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81470806
National Natural Science Foundation of Jiangsu Province BK20141496
Public Health Ministry of Jiangsu Province in the Talents in Medical Science Program RC201179
Corresponding Author Qi-Yun Tang, MD, PhD, Department of Gastroenterology, First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Rd, Nanjing 210029, China. tqy831@163.com
Key Words Colitis; Serum-and-glucocorticoid-inducible-kinase-1; MEK/ERK; Apoptosis; p53
Core Tip This study showed that serum-and-glucocorticoid-inducible-kinase-1 (SGK1) expression was significantly increased in the inflamed epithelia of patients with active Crohn’s disease (CD) in a TNBS-induced colitis model. At the cellular level, silencing of SGK1 inhibited the phosphorylation of mitogen-activated protein kinase kinase 1 (MEK1) and the downstream molecule ERK1/2, which induced the upregulation of p53 and Bcl-2-associated X protein, triggering subsequent cellular apoptosis and inhibition of proliferation in intestinal epithelial cells. A MEK1 inhibitor (i.e., U0126) was used to show that this was a MEK/ERK-dependent process. Co-immunoprecipitation analysis uncovered the mechanism of the interaction between SGK1 and MEK1. Our results provide a new therapeutic approach to CD therapy.
Publish Date 2015-05-30 13:32
Citation Bai JA, Xu GF, Yan LJ, Zeng WW, Ji QQ, Wu JD, Tang QY. SGK1 inhibits cellular apoptosis and promotes proliferation via the MEK/ERK/p53 pathway in colitis. World J Gastroenterol 2015; 21(20): 6180-6193
URL http://www.wjgnet.com/1007-9327/full/v21/i20/6180.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i20.6180
Full Article (PDF) WJG-21-6180.pdf
Full Article (Word) WJG-21-6180.doc
Manuscript File 14561-Review.docx
Answering Reviewers 14561-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form 14561-Conflict-of-interest statement.pdf
Copyright License Agreement 14561-Copyright assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document 14561-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 14561-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 14561-Language certificate.pdf
Peer-review Report 14561-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 14561-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 14561-Scientific misconduct check.pdf
Scientific Editor Work List 14561-Scientific editor work list.pdf