| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
|
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Intestinal genetic inactivation of caspase-8 diminishes migration of enterocytes
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Elke Kaemmerer, Paula Kuhn, Ursula Schneider, Min Kyung Jeon, Christina Klaus, Miriam Schiffer, Danika Weisner, Christian Liedtke, Jörg Jäkel, Lieven Nils Kennes, Ralf-Dieter Hilgers, Norbert Wagner and Nikolaus Gassler |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Deutsche Forschungsgemeinschaft |
DFG GA 785/5-1 (partially) |
| Deutsche Krebshilfe |
GA 109313 (partially) |
|
| Corresponding Author |
Dr. Nikolaus Gassler, MA, Professor, Institute of Pathology, RWTH Aachen University, Pauwelsstraße 30, 52074 Aachen, Germany. ngassler@ukaachen.de |
| Key Words |
Barrier function; Caspase 8; Cell migration; Inflammatory bowel disease; Intestinal morphogenesis |
| Core Tip |
Caspase 8 (Casp8) is involved in necroptosis and apoptosis of enterocytes. In addition, Casp8 is assumed as a mediator of cellular migration. Using cell culture experiments, migration of Casp8-deleted Caco2 cells is diminished. In vivo, enterocyte migration is significantly impaired in Casp8-deficient mice. The phenomenon is especially found along the duodenal crypt-villus axis. It is suggested that Casp8-dependent enterocyte migration could be involved in intestinal physiology and pathophysiology. |
| Publish Date |
2015-04-20 15:10 |
| Citation |
Kaemmerer E, Kuhn P, Schneider U, Jeon MK, Klaus C, Schiffer M, Weisner D, Liedtke C, Jäkel J, Kennes LN, Hilgers RD, Wagner N, Gassler N. Intestinal genetic inactivation of caspase-8 diminishes migration of enterocytes. World J Gastroenterol 2015; 21(15): 4499-4508 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i15/4499.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i15.4499 |
