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7/8/2015 12:00:00 PM | Browse: 676 | Download: 946
Publication Name World Journal of Gastroenterology
Manuscript ID 14637
Country/Territory Brazil
2014-10-17 08:44
Peer-Review Started
2014-10-18 15:13
To Make the First Decision
2014-12-02 09:24
Return for Revision
2014-12-03 17:08
2015-01-03 01:24
Second Decision
2015-02-11 22:51
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2015-02-12 17:32
Articles in Press
2015-02-13 11:19
Publication Fee Transferred
Edit the Manuscript by Language Editor
2015-06-08 23:37
Typeset the Manuscript
2015-06-25 10:19
Publish the Manuscript Online
2015-07-08 12:01
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Genetics and Heredity
Manuscript Type Basic Study
Article Title TLR2 and TLR4 polymorphisms influence mRNA and protein expression in colorectal cancer
Manuscript Source Unsolicited Manuscript
All Author List Marcela Alcântara Proença, Juliana Garcia de Oliveira, Aline Cristina Targa Cadamuro, Maysa Succi, João Gomes Netinho, Eny Maria Goloni-Bertolo, Érika Cristina Pavarino and Ana Elizabete Silva
Funding Agency and Grant Number
Funding Agency Grant Number
Brazilian agencies FAPESP 2012/15036-8
CNPq 304870/2012-9
Corresponding Author Ana Elizabete Silva, PhD, Department of Biology, UNESP, São Paulo State University, Rua Cristóvão Colombo, 2265, São José do Rio Preto 15054-000, SP, Brazil. anabete@ibilce.unesp.br
Key Words Toll-like receptor 2; Toll-like receptor 4; Colorectal cancer; Protein expression; Gene expression; Genetic polymorphisms
Core Tip This study investigated the influence of the toll-like receptor (TLR)2 and TLR4 functional polymorphisms on mRNA and protein expression levels in colorectal cancer samples and the association of these polymorphisms with the risk of developing this neoplasm. Increased expression of TLR2 (mRNA and protein) in tumor tissue was observed compared with adjacent normal tissue. Moreover, for the first time, the polymorphism TLR2-196 to -174del was associated with a higher risk of developing this type of cancer, and TLR2-196 to -174del allele carriers showed mRNA relative expression approximately two times higher than wild-genotype carriers. Thus, functional polymorphism in TLR2 may change gene expression levels, accentuating inflammation and aggravating the development of colorectal cancer.
Publish Date 2015-07-08 12:01
Citation Proença MA, de Oliveira JG, Cadamuro ACT, Succi M, Netinho JG, Goloni-Bertolo EM, Pavarino ÉC, Silva AE. TLR2 and TLR4 polymorphisms influence mRNA and protein expression in colorectal cancer. World J Gastroenterol 2015; 21(25): 7730-7741
URL http://www.wjgnet.com/1007-9327/full/v21/i25/7730.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i25.7730
Full Article (PDF) WJG-21-7730.pdf
Full Article (Word) WJG-21-7730.doc
Manuscript File 14637-Review.doc
Answering Reviewers 14637-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form 14637-Conflict-of-interest statement.pdf
Copyright License Agreement 14637-Copyright assignment.pdf
Data Sharing Statement 14637-Data sharing statement.pdf
Institutional Review Board Approval Form or Document 14637-Institutional review board statement.pdf
Peer-review Report 14637-Peer-review(s).pdf
Scientific Misconduct Check 14637-Scientific misconduct check.pdf
Scientific Editor Work List 14637-Scientific editor work list.pdf