Publication Name	World Journal of Gastroenterology
Manuscript ID	14668
Country	Japan

Received	2014-10-21 09:41
Peer-Review Started	2014-10-21 17:48
To Make the First Decision	2014-11-14 18:59
Return for Revision	2014-11-18 17:09
Revised	2014-12-09 21:12
Second Decision	2015-02-11 22:51
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2015-02-12 17:37
Articles in Press	2015-02-13 11:19
Publication Fee Transferred
Edit the Manuscript by Language Editor	2015-03-05 17:11
Typeset the Manuscript	2015-04-14 09:32
Publish the Manuscript Online	2015-04-27 16:22

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Randomized Controlled Trial
Article Title	Irsogladine maleate and rabeprazole in non-erosive reflux disease: A double-blind, placebo-controlled study
Manuscript Source	Unsolicited Manuscript
All Author List	Takayoshi Suzuki, Masashi Matsushima, Aya Masui, Shingo Tsuda, Jin Imai, Jun Nakamura, Yoko Tsukune, Tetsufumi Uchida, Hiroki Yuhara, Muneki Igarashi, Jun Koike and Tetsuya Mine
Funding Agency and Grant Number
Corresponding Author	Dr. Takayoshi Suzuki, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Tokai University School of Medicine, Isehara, Kanagawa 259-1193, Japan. takayosh@is.icc.u-tokai.ac.jp
Key Words	Irsogladine maleate; Rabeprazole; Non-erosive reflux disease; Randomized controlled trial; Frequency scale for the symptoms of gastroesophageal reflux disease; Quality of life
Core Tip	Proton pump inhibitor (PPI) therapy is considered the mainstay for the treatment of non-erosive reflux disease (NERD). However, it is less effective in NERD than it is in reflux esophagitis. This study evaluated the efficacy of adding irsogladine maleate (IM) to PPI therapy in the treatment of NERD. Adding IM to rabeprazole improved both the gastroesophageal reflux disease symptoms and the quality of the lives of patients with NERD showing no endoscopic abnormalities, a categorization that was based on the modified Los Angeles classification.
Publish Date	2015-04-27 16:22
Citation	Suzuki T, Matsushima M, Masui A, Tsuda S, Imai J, Nakamura J, Tsukune Y, Uchida T, Yuhara H, Igarashi M, Koike J, Mine T. Irsogladine maleate and rabeprazole in non-erosive reflux disease: A double-blind, placebo-controlled study. World J Gastroenterol 2015; 21(16): 5023-5031
URL	http://www.wjgnet.com/1007-9327/full/v21/i16/5023.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i16.5023

Full Article (PDF)	WJG-21-5023.pdf
Full Article (Word)	WJG-21-5023.doc
Manuscript File	14668-Review.docx
Answering Reviewers	14668-Answering reviewers.pdf
Copyright License Agreement	14668-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	Ethics_Committee_20141018133936.pdf
Non-Native Speakers of English Editing Certificate	Editing_Certificate_20141018134010.pdf
Peer-review Report	14668-Peer-review(s).pdf
Scientific Misconduct Check	14668-Scientific misconduct check.pdf
Scientific Editor Work List	14668-Scientific editor work list.pdf