Publication Name	World Journal of Stem Cells
Manuscript ID	14739
Country	Spain

Received	2014-10-22 08:24
Peer-Review Started	2014-10-22 10:09
To Make the First Decision	2014-11-27 11:46
Return for Revision	2014-11-28 11:47
Revised	2014-12-12 06:25
Second Decision	2015-03-11 13:38
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2015-03-20 10:50
Articles in Press	2015-03-20 10:50
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-05-15 14:30
Publish the Manuscript Online	2015-05-31 19:16

ISSN	1948-0210 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Cell Biology
Manuscript Type	Review
Article Title	Epigenetic regulation of stemness maintenance in the neurogenic niches
Manuscript Source	Invited Manuscript
All Author List	Raquel Montalbán-Loro, Ana Domingo-Muelas, Alexandra Bizy and Sacri R Ferrón
Funding Agency and Grant Number	Funding Agency Grant Number Ministerio de Ciencia e Innovación (SAF Program) to Sacri R Ferrón Spanish FPI fellowship to Raquel Montalbán-Loro Spanish FPU fellowship from the Ministerio de Educación y Ciencia to Ana Domingo-Muelas
Corresponding Author	Sacri R Ferrón, SR PhD, Departamento de Biología Celular, Facultad de Biología, Universidad de Valencia, C/ Dr. Moliner, 50, 46100 Burjassot, Spain. sacramento.rodriguez@uv.es
Key Words	Neurogenesis; Neural stem cell; Epigenetics; Gene expression regulation; Chromatin modifications; DNA methylation
Core Tip	Neural stem cells (NSCs) are capable of exten-sive self-renewal while preserving the ability to generate cell progeny that can differentiate into different cell types from the nervous system. Intrinsic mediators as well as extrinsic cues provided by the neurogenic niche (microenvironment where NSCs reside in vivo) are important for stem cell self-renewal and differentiation. Epigenetic changes, including alterations in DNA methylation, histone modifications and imprinting alter the way a gene interacts with the cell transcribing machinery, turning genes “on” or “off”. These heritable changes must be reversible and context-dependent being responsible of stem cell plasticity.
Publish Date	2015-05-31 19:16
Citation	Montalbán-Loro R, Domingo-Muelas A, Bizy A, Ferrón SR. Epigenetic regulation of stemness maintenance in the neurogenic niches. World J Stem Cells 2015; 7(4): 700-710
URL	http://www.wjgnet.com/1948-0210/full/v7/i4/700.htm
DOI	http://dx.doi.org/10.4252/wjsc.v7.i4.700

Full Article (PDF)	WJSC-7-700.pdf
Full Article (Word)	WJSC-7-700.doc
Manuscript File	14739-Review.docx
Answering Reviewers	14739-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	14739-Conflict-of-interest statement.pdf
Copyright License Agreement	14739-Copyright assignment.pdf
Peer-review Report	14739-Peer-review(s).pdf
Scientific Misconduct Check	14739-Scientific misconduct check.pdf
Scientific Editor Work List	14739-Scientific editor work list.pdf