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5/20/2015 5:01:00 PM | Browse: 818 | Download: 1019
Publication Name World Journal of Gastroenterology
Manuscript ID 14834
Country/Territory Sweden
Received
2014-10-27 08:04
Peer-Review Started
2014-10-28 09:38
To Make the First Decision
2014-11-14 18:50
Return for Revision
2014-11-18 19:45
Revised
2014-12-03 05:40
Second Decision
2015-01-23 16:05
Accepted by Journal Editor-in-Chief
2015-01-23 16:15
Accepted by Company Editor-in-Chief
2015-01-30 15:39
Articles in Press
2015-01-30 18:32
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-05-05 19:18
Publish the Manuscript Online
2015-05-20 17:01
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Case Report
Article Title Fecal stream diversion and mucosal cytokine levels in collagenous colitis: A case report
Manuscript Source Unsolicited Manuscript
All Author List Niki Daferera, Ashok Kumar Kumawat, Elisabeth Hultgren-Hörnquist, Simone Ignatova, Magnus Ström and Andreas Münch
Funding Agency and Grant Number
Corresponding Author Andreas Münch, MD, PhD, Division of Gastroenterology and Hepatology, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, 58185 Linköping, Sweden. andreas.munch@lio.se
Key Words Microscopic colitis; Collagenous colitis; Luminex; Mucosal cytokines; Fecal stream diversion
Core Tip The pathophysiology of collagenous colitis remains poorly understood. We describe a patient with chronic, active collagenous colitis who either failed to achieve clinical remission or experienced adverse effects with all medications given; therefore the patient was treated with a temporary loop ileostomy. We analyzed cytokine protein production with Luminex assays in colonic biopsy tissues obtained before and during fecal stream diversion (FSD) and after intestinal continuity was restored. Because FSD leads to clinical and histological remission, this study protocol provided a unique opportunity to study cytokine dynamics during different stages of disease. We were thus able to demonstrate that FSD was followed by a decrease in the levels of nearly all cytokines and that the restoration of bowel continuity increased the levels of the proinflammatory cytokines interleukin (IL)-2, IL-21 and IL-23.
Publish Date 2015-05-20 17:01
Citation Daferera N, Kumawat AK, Hultgren-Hörnquist E, Ignatova S, Ström M, Münch A. Fecal stream diversion and mucosal cytokine levels in collagenous colitis: A case report. World J Gastroenterol 2015; 21(19): 6065-6071
URL http://www.wjgnet.com/1007-9327/full/v21/i19/6065.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i19.6065
Full Article (PDF) WJG-21-6065.pdf
Full Article (Word) WJG-21-6065.doc
Manuscript File 14834-Review.docx
Answering Reviewers 14834-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form 14834-Conflict-of-interest statement.pdf
Copyright License Agreement 14834-Copyright assignment.pdf
Institutional Review Board Approval Form or Document 14834-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 14834-Language certificate.pdf
Peer-review Report 14834-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 14834-Journal Editor-in-Chief's Review Report.pdf
Scientific Misconduct Check 14834-CrossCheck.jpg
Scientific Editor Work List 14834-Scientific editor work list.pdf