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7/6/2015 6:45:00 PM | Browse: 878 | Download: 1443
Publication Name World Journal of Nephrology
Manuscript ID 14965
Country/Territory United States
Received
2014-11-02 12:27
Peer-Review Started
2014-11-09 14:06
To Make the First Decision
2014-11-27 12:07
Return for Revision
2014-12-07 18:26
Revised
2014-12-08 01:33
Second Decision
2015-05-08 17:48
Accepted by Journal Editor-in-Chief
2015-05-11 03:56
Accepted by Company Editor-in-Chief
2015-05-18 17:08
Articles in Press
2015-05-18 17:08
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-06-30 15:43
Publish the Manuscript Online
2015-07-06 18:45
ISSN 2220-6124 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Biochemistry & Molecular Biology
Manuscript Type Minireviews
Article Title Epigenetics of epithelial Na+ channel-dependent sodium uptake and blood pressure regulation
Manuscript Source Invited Manuscript
All Author List Wenzheng Zhang
Funding Agency and Grant Number
Funding Agency Grant Number
National Institutes of Health Grant 2R01 DK080236 06A1
Corresponding Author Wenzheng Zhang, Associate Professor, Department of Internal Medicine, University of Texas Medical School at Houston, MSB 5.135, 6431 Fannin, Houston, TX 77030, United States. wenzheng.zhang@uth.tmc.edu
Key Words Gene transcription; Chromatin; Epithelial sodium channel; Histone; Blood pressure
Core Tip The epithelial Na+ channel (ENaC) is a key player in sodium transport and blood pressure control. This minireview summarizes the epigenetic mechanisms governing the transcription of ?ENaC. The epigenetic control involves Dot1a-Af9-mediated repression through targeted hypermethylation of histone H3 K79. Aldosterone relieves the repression by decreasing Dot1a and Af9 mRNA levels and by weakening the protein-protein interaction between Dot1a and Af9 interaction via Sgk1-catalyzed Af9 phosphorylation. Aldosterone-independent mechanism involves Af17 as a competitor of Af9 for binding Dot1a and stimulator of Dot1a nuclear export. Af17-/- mice exhibit decreased Na+ reabsorption and lowered blood pressure, indicating the significance of this epigenetic control.
Publish Date 2015-07-06 18:45
Citation Zhang W. Epigenetics of epithelial Na+ channel-dependent sodium uptake and blood pressure regulation. World J Nephrol 2015; 4(3): 363-366
URL http://www.wjgnet.com/2220-6124/full/v4/i3/363.htm
DOI http://dx.doi.org/10.5527/wjn.v4.i3.363
Full Article (PDF) WJN-4-363.pdf
Full Article (Word) WJN-4-363.doc
Manuscript File 14965-Review.doc
Answering Reviewers 14965-Answering reviewers.pdf
Audio Core Tip 14965-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 14965-Conflict-of-interest statement.pdf
Copyright License Agreement 14965-Copyright assignment.pdf
Peer-review Report 14965-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 14965-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 14965-Scientific misconduct check.pdf
Scientific Editor Work List 14965-Scientific editor work list.pdf