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6/11/2015 10:11:00 AM | Browse: 923 | Download: 1108
Publication Name World Journal of Gastroenterology
Manuscript ID 14987
Country/Territory China
Received
2014-11-03 08:30
Peer-Review Started
2014-11-03 09:39
To Make the First Decision
2014-12-26 13:32
Return for Revision
2015-01-05 11:32
Revised
2015-02-03 19:26
Second Decision
2015-02-10 21:20
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2015-02-11 15:27
Articles in Press
2015-02-11 16:16
Publication Fee Transferred
Edit the Manuscript by Language Editor
2015-03-05 04:53
Typeset the Manuscript
2015-05-20 18:31
Publish the Manuscript Online
2015-06-11 10:11
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Retrospective Study
Article Title Precore/basal core promoter mutants quantification throughout phases of hepatitis B virus infection by Simpleprobe
Manuscript Source Unsolicited Manuscript
All Author List Wen-Hui Tu, Ying Lv, Yong-Mei Zhang, Wei Hou, Jin-Yu Wang, Yi-Jun Zhang, Hong-Yan Liu, Hao-Xiang Zhu, Yan-Li Qin, Ri-Cheng Mao and Ji-Ming Zhang
Funding Agency and Grant Number
Funding Agency Grant Number
National Science and Technology Major Project of China 2012ZX10002007-001-002
National Science and Technology Major Project of China 2013ZX10002001 (to Zhang JM)
National Natural Science Foundation of China 81271833
National Natural Science Foundation of China 81471933 (to Zhang JM)
Science and Technology Plan Project of Taizhou, Zhejiang province 1402ky19 (to Tu WH and Hou W)
Scientific Research Project of Taizhou University, Zhejiang province 2014PY054 (to Tu WH and Hou W)
Corresponding Author Ji-Ming Zhang, MD, Department of Infectious Disease, Huashan Hospital, Fudan University, No. 12 Wulumuqi Zhong Road, Shanghai 200040, China. jmzhang@fudan.edu.cn
Key Words Precore mutant; Basal core promoter mutant; Hepatitis B virus; Quantification; Hepatitis B early antigen titers
Core Tip During the natural history of hepatitis B virus infection, no evidence for the correlation between the dynamic alteration of precore/basal core promoter (PC/BCP) mutated strains and hepatitis B early antigen titers has been obtained by qualitative analysis. Using Simpleprobe ultrasensitive quantification of the wild-type and mutated hepatitis B virus (HBV) strains, we provided new insights into the process by which PC/BCP-mutated strains become dominant during the natural course of infection. Thus, we provide important clues for the evaluation of HBV infection status and the corresponding host immune responses.
Publish Date 2015-06-11 10:11
Citation Tu WH, Lv Y, Zhang YM, Hou W, Wang JY, Zhang YJ, Liu HY, Zhu HX, Qin YL, Mao RC, Zhang JM. Precore/basal core promoter mutants quantification throughout phases of hepatitis B virus infection by Simpleprobe. World J Gastroenterol 2015; 21(21): 6639-6648
URL http://www.wjgnet.com/1007-9327/full/v21/i21/6639.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i21.6639
Full Article (PDF) WJG-21-6639.pdf
Full Article (Word) WJG-21-6639.doc
Manuscript File 14987-Review.docx
Answering Reviewers 14987-Answering reviewers.pdf
Copyright License Agreement 14987-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 14987-Language certificate.pdf
Peer-review Report 14987-Peer-review(s).pdf
Scientific Misconduct Check 14987-Scientific misconduct check.pdf
Scientific Editor Work List 14987-Scientific editor work list.pdf