Publication Name	World Journal of Critical Care Medicine
Manuscript ID	15072
Country

Received	2014-11-07 14:26
Peer-Review Started	2014-11-08 21:15
To Make the First Decision	2015-01-08 14:03
Return for Revision	2015-01-10 20:52
Revised	2015-01-27 18:41
Second Decision	2015-04-01 14:54
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2015-04-09 16:45
Articles in Press	2015-04-09 16:45
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-07-27 17:10
Publish the Manuscript Online	2015-08-17 18:00

ISSN	2220-3141(online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Critical Care Medicine
Manuscript Type	Minireviews
Article Title	Severe scrub typhus infection: Clinical features, diagnostic challenges and management
Manuscript Source	Invited Manuscript
All Author List	John Victor Peter, Thomas I Sudarsan, John Anthony J Prakash and George M Varghese
Funding Agency and Grant Number
Corresponding Author	Dr. John Victor Peter, Professor, Head, Medical Intensive Care Unit, Christian Medical College, Vellore 632004, Tamil Nadu, India. peterjohnvictor@yahoo.com.au
Key Words	Rickettsia; DiagnRickettsia; Diagnosis; Management; Outcome; Multi-organ failure osis; Management; Outcome; Multi-organ failure
Core Tip	Scrub typhus is an important differential dia-gnosis in patients who present with acute undiffer-entiated fever in South East Asia. Since the presentation may be non-specific, with features of organ failure in those with severe infection, early diagnosis and appropriate management is crucial. The presence of an eschar suggests scrub typhus infection. The diagnosis may be confirmed on serological assays, the reference test being the indirect immunofluorescence test for the detection of IgM antibodies. In those with mild infection, fever defervescence occurs in about 2-d with Doxycycline therapy.
Publish Date	2015-08-17 18:00
Citation	Peter JV, Sudarsan TI, Prakash JAJ, Varghese GM. Severe scrub typhus infection: Clinical features, diagnostic challenges and management. World J Crit Care Med 2015; 4(3): 244-250
URL	http://www.wjgnet.com/2220-3141/full/v4/i3/244.htm
DOI	http://dx.doi.org/10.5492/wjccm.v4.i3.244

Full Article (PDF)	WJCCM-4-244.pdf
Full Article (Word)	WJCCM-4-244.doc
Manuscript File	15072-Review.doc
Answering Reviewers	15072-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	15072-Conflict-of-interest statement.pdf
Copyright License Agreement	15072-Copyright assignment.pdf
Peer-review Report	15072-Peer-review(s).pdf
Scientific Misconduct Check	15072-Scientific misconduct check.pdf
Scientific Editor Work List	15072-Scientific editor work list.pdf