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5/18/2015 5:02:00 PM | Browse: 954 | Download: 1734
Publication Name World Journal of Gastroenterology
Manuscript ID 15094
Country/Territory China
Received
2014-11-08 12:09
Peer-Review Started
2014-11-08 21:11
To Make the First Decision
2014-12-11 20:23
Return for Revision
2014-12-16 08:57
Revised
2014-12-31 09:52
Second Decision
2015-02-02 10:28
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2015-02-13 10:13
Articles in Press
2015-02-13 11:28
Publication Fee Transferred
Edit the Manuscript by Language Editor
2015-03-31 09:44
Typeset the Manuscript
2015-04-28 12:12
Publish the Manuscript Online
2015-05-18 17:02
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title Dihydromyricetin alleviates carbon tetrachloride-induced acute liver injury via JNK-dependent mechanism in mice
Manuscript Source Unsolicited Manuscript
All Author List Jun Xie, Jie Liu, Tu-Ming Chen, Qing Lan, Qing-Yu Zhang, Bin Liu, Dong Dai, Wei-Dong Zhang, Li-Ping Hu and Run-Zhi Zhu
Funding Agency and Grant Number
Funding Agency Grant Number
Initial Fund of Guangdong Medical College XB1338
Medical Research Fund of Guangdong Province B2014306
Research Fund of Guangdong Medical College M2013024
Corresponding Author Run-Zhi Zhu, PhD, Clinical Research Center, Xuyi People’s Hospital, No. 3 East Huaihe Road, Xucheng Town, Xuyi 211700, Jiangsu Province, China. hepatolab@163.com
Key Words Dihydromyricetin; Liver regeneration; Tumor necrosis factor-α
Core Tip Our research confirmed that dihydromyricetin (DHM) plays an anti-inflammatory role in the carbon tetrachloride (CCl4) induced acute liver injury mice. It was shown that DHM could alleviate CCl4-induced acute liver injury by reducing apoptosis and accelerating proliferation of hepatocytes. Furthermore, DHM treatment up-regulated Jun kinase expression in liver tissue, and the mice which were injected with SP600125 could not survive in the acute liver failure induced by lethal dose CCl4 injection.
Publish Date 2015-05-18 17:02
Citation Xie J, Liu J, Chen TM, Lan Q, Zhang QY, Liu B, Dai D, Zhang WD, Hu LP, Zhu RZ. Dihydromyricetin alleviates carbon tetrachloride-induced acute liver injury via JNK-dependent mechanism in mice. World J Gastroenterol 2015; 21(18): 5473-5481
URL http://www.wjgnet.com/1007-9327/full/v21/i18/5473.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i18.5473
Full Article (PDF) WJG-21-5473.pdf
Full Article (Word) WJG-21-5473.doc
Manuscript File 15094-Review.doc
Answering Reviewers 15094-Answering reviewers.pdf
Biostatistics Review Certificate 15094-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 15094-Conflict-of-interest statement.pdf
Copyright License Agreement 15094-Copyright assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document 15094-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 15094-Institutional review board statement.pdf
Peer-review Report 15094-Peer-review(s).pdf
Scientific Misconduct Check 15094-Scientific misconduct check.pdf
Scientific Editor Work List 15094-Scientific editor work list.pdf