| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
|
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Neurosciences |
| Manuscript Type |
Review |
| Article Title |
Gut-brain connection: The neuroprotective effects of the anti-diabetic drug liraglutide
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Emanuel Monteiro Candeias, Inês Carolina Sebastião, Susana Maria Cardoso, Sónia Catarina Correia, Cristina Isabel Carvalho, Ana Isabel Plácido, Maria Sancha Santos, Catarina Resende Oliveira, Paula Isabel Moreira and Ana Isabel Duarte |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| FEDER (Programa Operacional Factores de Competitividade - COMPETE) |
|
| Portuguese funds via Portuguese Science Foundation (FCT) |
PTDC/SAU-NMC/110990/2009 |
| Portuguese funds via Portuguese Science Foundation (FCT) |
PTDC/SAU-TOX/117481/2010 |
| Portuguese funds via Portuguese Science Foundation (FCT) |
Pest/SAU/LA0001/2011 |
| Portuguese funds via Portuguese Science Foundation (FCT) |
SFRH/BD/90036/2012 |
| Portuguese funds via Portuguese Science Foundation (FCT) |
PTDC/SAU-TOX/117481/2010 |
| Portuguese funds via Portuguese Science Foundation (FCT) |
SFRH/BPD/95770/2013 |
| Portuguese funds via Portuguese Science Foundation (FCT) |
SFRH/BPD/84163/2012 |
| Portuguese funds via Portuguese Science Foundation (FCT) |
QREN DoIT, “DIAMARKER PROJECT”, n.º 13853 |
| Portuguese funds via Portuguese Science Foundation (FCT) |
SFRH/BD/73388/2010 |
| Portuguese funds via Portuguese Science Foundation (FCT) |
SFRH/BPD/84473/2012 |
|
| Corresponding Author |
Dr. Ana Isabel Duarte, CNC - Center for Neuroscience and Cell Biology, Rua Larga, Faculty of Medicine (1st Floor), University of Coimbra, Largo Marquês de Pombal, 3004-517 Coimbra, Portugal. anaimduarte@gmail.com |
| Key Words |
Type 2 diabetes; Glucagon-like peptide-1; Gut; Brain; Insulin; Liraglutide; Alzheimer disease; Neuroprotection |
| Core Tip |
Glucagon-like peptide-1 (GLP-1) physiological responses are dependent on a gut-brain axis and receptor (GLP-1R) activation. GLP-1Rs are widely expressed throughout the body, including several brain areas. GLP-1 may readily diffuse across the blood-brain-barrier, activating neuroprotective pathways. Given the native GLP-1 short half-life, liraglutide has been developed with a highly increased half-life, allowing its use to treat type 2 diabetes (T2D). Given T2D patients increased risk for obesity and dementia [e.g., Alzheimer disease (AD)], and evidence from preclinical studies, whereby liraglutide showed impressive neuroprotective effects, clinical studies are underway to test the role of liraglutide on weigh control and AD. |
| Publish Date |
2015-06-20 17:24 |
| Citation |
Candeias EM, Sebastião IC, Cardoso SM, Correia SC, Carvalho CI, Plácido AI, Santos MS, Oliveira CR, Moreira PI, Duarte AI. Gut-brain connection: The neuroprotective effects of the anti-diabetic drug liraglutide. World J Diabetes 2015; 6(6): 807-827 |
| URL |
http://www.wjgnet.com/1948-9358/full/v6/i6/807.htm |
| DOI |
http://dx.doi.org/10.4239/wjd.v6.i6.807 |
