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12/10/2015 10:35:00 AM | Browse: 752 | Download: 723
Publication Name World Journal of Gastroenterology
Manuscript ID 15343
Country/Territory United States
Received
2014-11-22 15:04
Peer-Review Started
2014-11-23 16:30
To Make the First Decision
2014-12-26 13:30
Return for Revision
2015-01-05 17:10
Revised
2015-01-16 00:00
Second Decision
2015-02-10 21:26
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2015-02-11 15:50
Articles in Press
2015-02-11 16:20
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-03-08 19:07
Publish the Manuscript Online
2015-03-19 16:57
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Minireviews
Article Title Biomarkers in nonalcoholic fatty liver disease-the emperor has no clothes?
Manuscript Source Invited Manuscript
All Author List Madhusudana Girija Sanal
Funding Agency and Grant Number
Funding Agency Grant Number
IIP fellowship (2013-2014), Albert Einstein College of Medicine, New York, through the generosity of the Gruss Lipper Family Foundation
Corresponding Author Madhusudana Girija Sanal, MD, PhD, IIP Research Fellow, Albert Einstein College of Medicine, Room#323, Ullmann Building, 1300 Morris Park Avenue, Bronx, NY 10461, United States. sanalmg@gmail.com
Key Words Nonalcoholic fatty liver disease; Biomarkers; Fibrosis; Cirrhosis; Steatohepatitis; Liver biopsy
Core Tip Nonalcoholic fatty liver disease (NAFLD) is not a single disease, but encompasses a spectrum of diseases and this makes it very difficult to find highly specific and sensitive biomarkers. We should therefore aim to find relevant prognostic markers rather than accurate diagnostic markers which will help to minimize the frequency of liver biopsies to evaluate disease progression. There is no evidence that biopsy and detailed staging of NAFLD is important in the NAFLD management and benefits patients. Finally, there is no evidence based treatment for NAFLD other than management of 'metabolic syndrome' by pharmacological or non-pharmacological (lifestyle management/surgical) approaches.
Publish Date 2015-03-19 16:57
Citation Sanal MG. Biomarkers in nonalcoholic fatty liver disease-the emperor has no clothes? World J Gastroenterol 2015; 21(11): 3223-3231
Url http://www.wjgnet.com/1007-9327/full/v21/i11/3223.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i11.3223
Full Article (PDF) WJG-21-3223.pdf
Full Article (Word) WJG-21-3223.doc
Manuscript File 15343-Review.docx
Answering Reviewers 15343-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form 15343-Conflict-of-interest statement.pdf
Copyright License Agreement 15343-Copyright assignment.pdf
Peer-review Report 15343-Peer-review(s).pdf
Scientific Misconduct Check 15343-Scientific misconduct check.pdf
Scientific Editor Work List 15343-Scientific editor work list.pdf