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Articles Published Processes
5/30/2015 1:35:00 PM | Browse: 1170 | Download: 2290
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Received |
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2014-11-28 09:56 |
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Peer-Review Started |
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2014-11-28 11:00 |
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To Make the First Decision |
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2014-12-26 13:24 |
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Return for Revision |
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2014-12-31 09:12 |
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Revised |
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2015-01-14 07:59 |
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Second Decision |
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2015-02-11 22:58 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2015-02-13 10:31 |
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Articles in Press |
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2015-02-13 11:28 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2015-03-12 00:29 |
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Typeset the Manuscript |
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2015-05-14 16:29 |
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Publish the Manuscript Online |
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2015-05-30 13:32 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
CD97 promotes gastric cancer cell proliferation and invasion through exosome-mediated MAPK signaling pathway
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Chao Li, Da-Ren Liu, Guo-Gang Li, Hou-Hong Wang, Xiao-Wen Li, Wei Zhang, Yu-Lian Wu and Li Chen |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81101837 |
| Research Fund for the Doctoral Program of Higher Education of China |
20110101120129 |
| Zhejiang Medical Health Science and Technology Plan |
2013KYB124 |
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| Corresponding Author |
Yu-Lian Wu, PhD, Department of Surgery, Second Affiliated Hospital, College of Medicine, Zhejiang University, No. 88 Jiefang Road, Hangzhou 310021, Zhejiang Province, China. wuyulian@medmail.com.cn |
| Key Words |
CD97; Exosome; Proliferation; Invasion; miRNA; Gastric cancer |
| Core Tip |
CD97, belongs to the epidermal growth factor-seven-transmembrane subfamily, and has been found to promote proliferation and invasion of gastric cancer cells. However, the underlying mechanism is poorly understood. In this study, we found that exosomes isolated from gastric cancer cells with high CD97 expression promoted tumor cell proliferation and invasion. Furthermore, through microarray and western blot analyses, MAPK signaling pathway activation was observed when cells were treated with those exosomes. These results indicated that CD97 promotes gastric cancer cell proliferation and invasion in vitro, at least in part, through the exosome-mediated MAPK signaling pathway, and exosomal miRNAs are probably involved in activation of the CD97-associated pathway. |
| Publish Date |
2015-05-30 13:32 |
| Citation |
Li C, Liu DR, Li GG, Wang HH, Li XW, Zhang W, Wu YL, Chen L. CD97 promotes gastric cancer cell proliferation and invasion through exosome-mediated MAPK signaling pathway. World J Gastroenterol 2015; 21(20): 6215-6228 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i20/6215.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i20.6215 |
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