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7/6/2015 6:45:00 PM | Browse: 1092 | Download: 1369
Publication Name World Journal of Nephrology
Manuscript ID 15495
Country/Territory Germany
Received
2014-11-27 20:10
Peer-Review Started
2014-11-28 15:42
To Make the First Decision
2014-12-26 13:16
Return for Revision
2015-01-01 17:02
Revised
2015-01-12 21:59
Second Decision
2015-04-22 17:09
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2015-05-06 15:35
Articles in Press
2015-05-06 15:45
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-06-30 14:14
Publish the Manuscript Online
2015-07-06 18:45
ISSN 2220-6124 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Critical Care Medicine
Manuscript Type Review
Article Title Pharmacokinetic and pharmacodynamic considerations of antimicrobial drug therapy in cancer patients with kidney dysfunction
Manuscript Source Invited Manuscript
All Author List Frieder Keller, Bernd Schröppel and Ulla Ludwig
Funding Agency and Grant Number
Corresponding Author Frieder Keller, MD, Section of Nephrology, Department of Internal Medicine 1, Center for Internal Medicine, University Hospital, Albert-Einstein-Allee 23, D-89070 Ulm, Germany. frieder.keller@uni-ulm.de
Key Words Anti-infective drugs; Cancer; Kidney function; Pharmacodynamics; Pharmacokinetics; Dose adjustmen; NEPharm
Core Tip Cancer patients are at an increased risk for both infection and kidney dysfunction. Infections need immediate treatment; during the further course, kidney function must be taken into account. Almost any drug can be adjusted to any kidney function in every patient. Observation of the pharmacokinetic principles allows avoiding adverse events. Observation of the pharmacodynamic principles is needed to obtain anti-infective success. The target concentration for anti-infective drugs with a concentration-dependent effect is the high peak level. The target concentration for anti-infective drugs with a time-dependent effect is the high trough level. When in doubt, the peak should be the target.
Publish Date 2015-07-06 18:45
Citation Keller F, Schröppel B, Ludwig U. Pharmacokinetic and pharmacodynamic considerations of antimicrobial drug therapy in cancer patients with kidney dysfunction. World J Nephrol 2015; 4(3): 330-344
URL http://www.wjgnet.com/2220-6124/full/v4/i3/330.htm
DOI http://dx.doi.org/10.5527/wjn.v4.i3.330
Full Article (PDF) WJN-4-330.pdf
Full Article (Word) WJN-4-330.doc
Manuscript File 15495-Review.docx
Answering Reviewers 15495-Answering reviewers.pdf
Audio Core Tip 15495-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 15495-Conflict-of-interest statement.pdf
Copyright License Agreement 15495-Copyright assignment.pdf
Peer-review Report 15495-Peer-review(s).pdf
Scientific Misconduct Check 15495-Scientific misconduct check.pdf
Scientific Editor Work List 15495-Scientific editor work list.pdf