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4/27/2015 4:29:00 PM | Browse: 602 | Download: 913
Publication Name World Journal of Gastroenterology
Manuscript ID 15531
Country/Territory Mexico
2014-11-28 18:38
Peer-Review Started
2014-12-01 19:52
To Make the First Decision
2014-12-26 13:22
Return for Revision
2014-12-31 09:16
2015-01-16 10:48
Second Decision
2015-01-31 09:31
Accepted by Journal Editor-in-Chief
2015-02-01 22:30
Accepted by Company Editor-in-Chief
2015-02-13 10:37
Articles in Press
2015-02-13 11:31
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-04-15 15:48
Publish the Manuscript Online
2015-04-27 16:22
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Clinical Trials Study
Article Title Metadoxine improves the three- and six-month survival rates in patients with severe alcoholic hepatitis
Manuscript Source Unsolicited Manuscript
All Author List Fátima Higuera-de la Tijera, Alfredo I Servín-Caamaño, Aurora E Serralde-Zúñiga, Javier Cruz-Herrera, Eduardo Pérez-Torres, Juan M Abdo-Francis, Francisco Salas-Gordillo and José L Pérez-Hernández
Funding Agency and Grant Number
Funding Agency Grant Number
Fatima Higuera-de la Tijera through the “Angeles Espinosa Yglesias 2010” stimulus granted by the FUNSALUD AC, AMPARO Foundation and FUNDHEPA AC, Mexico
Corresponding Author Fátima Higuera-de la Tijera, MD, MSc, Liver Clinic, Gastroenterology Department, Hospital General de México, Dr. Eduardo Liceaga, Dr. Balmis 148, Mexico City 06720, Mexico. fatimahiguera@yahoo.com.mx
Key Words Alcoholic hepatitis; Metadoxine; Survival; Alcohol abstinence
Core Tip Severe alcoholic hepatitis (AH) has a high mortality rate. Oxidative stress and the depletion of mitochondrial glutathione are factors implicated in injury to the liver. Metadoxine (MTD), an antioxidant that participates in the synthesis of glutathione and inhibits hepatic lipid accumulation, appears to be a novel therapeutic agent in patients with severe AH because it improves their 3- and 6-mo survival. The patients who received MTD were also better able to abstain from alcohol use, which is a key factor contributing to the improved survival in patients with severe AH.
Publish Date 2015-04-27 16:22
Citation Higuera-de la Tijera F, Servín-Caamaño AI, Serralde-Zúñiga AE, Cruz-Herrera J, Pérez-Torres E, Abdo-Francis JM, Salas-Gordillo F, Pérez-Hernández JL. Metadoxine improves the three- and six-month survival rates in patients with severe alcoholic hepatitis. World J Gastroenterol 2015; 21(16): 4975-4985
URL http://www.wjgnet.com/1007-9327/full/v21/i16/4975.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i16.4975
Full Article (PDF) WJG-21-4975.pdf
Full Article (Word) WJG-21-4975.doc
Manuscript File 15531-Review.doc
Answering Reviewers 15531-Answering reviewers.pdf
Biostatistics Review Certificate 15531-Biostatistics statement.pdf
Clinical Trial Registration Statement 15531-Clinical trial registration statement.pdf
Conflict-of-Interest Disclosure Form 15531-Conflict-of-interest statement.pdf
Copyright License Agreement 15531-Copyright assignment.pdf
Data Sharing Statement 15531-Data sharing statement.pdf
Signed Informed Consent Form(s) or Document(s) 15531-Clinical trial registration.pdf
Institutional Review Board Approval Form or Document 15531-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 15531-Language certificate.pdf
Peer-review Report 15531-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 15531-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 15531-Scientific misconduct check.pdf
Scientific Editor Work List 15531-Scientific editor work list.pdf