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Articles Published Processes
4/27/2015 4:29:00 PM | Browse: 1069 | Download: 1810
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Received |
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2014-11-28 18:38 |
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Peer-Review Started |
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2014-12-01 19:52 |
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To Make the First Decision |
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2014-12-26 13:22 |
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Return for Revision |
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2014-12-31 09:16 |
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Revised |
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2015-01-16 10:48 |
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Second Decision |
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2015-01-31 09:31 |
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Accepted by Journal Editor-in-Chief |
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2015-02-01 22:30 |
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Accepted by Company Editor-in-Chief |
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2015-02-13 10:37 |
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Articles in Press |
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2015-02-13 11:31 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2015-04-15 15:48 |
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Publish the Manuscript Online |
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2015-04-27 16:22 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Clinical Trials Study |
| Article Title |
Metadoxine improves the three- and six-month survival rates in patients with severe alcoholic hepatitis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Fátima Higuera-de la Tijera, Alfredo I Servín-Caamaño, Aurora E Serralde-Zúñiga, Javier Cruz-Herrera, Eduardo Pérez-Torres, Juan M Abdo-Francis, Francisco Salas-Gordillo and José L Pérez-Hernández |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Fatima Higuera-de la Tijera through the “Angeles Espinosa Yglesias 2010” stimulus granted by the FUNSALUD AC, AMPARO Foundation and FUNDHEPA AC, Mexico |
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| Corresponding Author |
Fátima Higuera-de la Tijera, MD, MSc, Liver Clinic, Gastroenterology Department, Hospital General de México, Dr. Eduardo Liceaga, Dr. Balmis 148, Mexico City 06720, Mexico. fatimahiguera@yahoo.com.mx |
| Key Words |
Alcoholic hepatitis; Metadoxine; Survival; Alcohol abstinence |
| Core Tip |
Severe alcoholic hepatitis (AH) has a high mortality rate. Oxidative stress and the depletion of mitochondrial glutathione are factors implicated in injury to the liver. Metadoxine (MTD), an antioxidant that participates in the synthesis of glutathione and inhibits hepatic lipid accumulation, appears to be a novel therapeutic agent in patients with severe AH because it improves their 3- and 6-mo survival. The patients who received MTD were also better able to abstain from alcohol use, which is a key factor contributing to the improved survival in patients with severe AH. |
| Publish Date |
2015-04-27 16:22 |
| Citation |
Higuera-de la Tijera F, Servín-Caamaño AI, Serralde-Zúñiga AE, Cruz-Herrera J, Pérez-Torres E, Abdo-Francis JM, Salas-Gordillo F, Pérez-Hernández JL. Metadoxine improves the three- and six-month survival rates in patients with severe alcoholic hepatitis. World J Gastroenterol 2015; 21(16): 4975-4985 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i16/4975.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i16.4975 |
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