Publication Name	World Journal of Gastroenterology
Manuscript ID	15687
Country	China

Received	2014-12-04 09:16
Peer-Review Started	2014-12-05 10:57
To Make the First Decision	2014-12-26 13:27
Return for Revision	2014-12-29 11:53
Revised	2015-01-11 11:15
Second Decision	2015-02-02 10:26
Accepted by Journal Editor-in-Chief	2015-02-02 16:42
Accepted by Executive Editor-in-Chief	2015-02-12 17:51
Articles in Press	2015-02-13 11:23
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-06-25 16:17
Publish the Manuscript Online	2015-07-08 12:01

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Cell Biology
Manuscript Type	Case Report
Article Title	Monitoring disease progression and treatment efficacy with circulating tumor cells in esophageal squamous cell carcinoma: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Yuan-Yuan Qiao, Kai-Xuan Lin, Ze Zhang, Da-Jin Zhang, Cheng-He Shi, Ming Xiong, Xiu-Hua Qu and Xiao-Hang Zhao
Funding Agency and Grant Number	Funding Agency Grant Number National High-tech R&D Program of China (863 Program) 2012AA020206 National High-tech R&D Program of China (863 Program) 2014CBA02002 National High-tech R&D Program of China (863 Program) 2013ZX10002009-001-004 National Basic Research Program of China（973 Program） 2011CB910703 National Natural Science Foundation of China 81372591 National Natural Science Foundation of China 81321091 Center for Marine Medicine and Rescue of Tsinghua University of China
Corresponding Author	Xiao-Hang Zhao, PhD, State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 17 Panjiayuan Nanli, Beijing 100021, China. zhaoxh@cicams.ac.cn
Key Words	Individualized treatment; Adjuvant therapy; Esophageal squamous cell carcinoma; Circulating tumor cells
Core Tip	We report a follow-up of a 47-year-old male patient with esophageal squamous cell carcinoma in this study. In addition to the conventional examination, a novel workflow was performed to detect circulating tumor cells (CTCs). We evaluated the relationship between CTC characteristics and other tests. The serum tumor markers were normal and thus did not appear to reflect changes in the disease, whereas the number of CTCs fluctuated with the disease progression and treatment and coincided with imaging studies performed during the follow-up. This case highlights CTCs as a useful diagnostic tool with potential applications during treatment.
Publish Date	2015-07-08 12:01
Citation	Qiao YY, Lin KX, Zhang Z, Zhang DJ, Shi CH, Xiong M, Qu XH, Zhao XH. Monitoring disease progression and treatment efficacy with circulating tumor cells in esophageal squamous cell carcinoma: A case report. World J Gastroenterol 2015; 21(25): 7921-7928
URL	http://www.wjgnet.com/1007-9327/full/v21/i25/7921.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i25.7921

Full Article (PDF)	WJG-21-7921.pdf
Full Article (Word)	WJG-21-7921.doc
Manuscript File	15687-Review.doc
Answering Reviewers	15687-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	15687-Conflict-of-interest statement.pdf
Copyright License Agreement	15687-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s)	Informed_Consent_Statement_20141203174447.doc
Institutional Review Board Approval Form or Document	15687-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	15687-Language certificate.PDF
Peer-review Report	15687-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	15687-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	15687-Scientific misconduct check.pdf
Scientific Editor Work List	15687-Scientific editor work list.pdf