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Publication Name World Journal of Gastroenterology
Manuscript ID 1569
Country/Territory Sweden
Received
2012-12-20 15:32
Peer-Review Started
2012-12-23 19:03
To Make the First Decision
2013-02-01 21:47
Return for Revision
2013-03-20 21:29
Revised
2013-04-04 03:06
Second Decision
2013-06-06 10:09
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2013-06-06 12:37
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2013-07-26 18:32
Publish the Manuscript Online
2013-08-13 11:13
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Genetics and Heredity
Manuscript Type Autobiography
Article Title Analysis of single nucleotide polymorphisms in the region of CLDN2-MORC4 in relation to inflammatory bowel disease
Manuscript Source Invited Manuscript
All Author List Jan Söderman, Elisabeth Norén, Malin Christiansson, Hanna Bragde, Raphaele Thiébaut, Jean-Pierre Hugot, Curt Tysk, Colm A O’Morain, Miquel Gassull, Yigael Finkel, Jean-Frédéric Colombel, Marc Lémann and Sven Almer
Funding Agency and Grant Number
Funding Agency Grant Number
Futurum - the academy of healthcare, County council of Jönköping
Swedish Society of Medicine
Research Council of South-East Sweden (FORSS)
County Council of Östergötland (ALF-Grants)
Corresponding Author Elisabeth Norén, BSc, Division of Medical Diagnostics, Ryhov County Hospital, Sjukhusgatan, 55185 Jönköping, Sweden. elisabeth.noren@lj.se
Key Words Crohn’s disease; Genetic predisposition; Inflammatory bowel disease; Single nucleotide polymorphism; Tight junctions
Core Tip Tight junction proteins are key components in the regulation of paracellular permeability and therefore we considered claudin genes as candidate genes in the study. Association was identified between a single nucleotide polymorphism marker (rs12014762) in the CLDN2-MORC4 region and the occurrence of Crohn’s disease (CD) in a Swedish population. Additionally, a nonsynonymous coding single nucleotide polymorphism (rs6622126) in MORC4 was associated to CD. Our findings add further support for a genetically impaired intestinal epithelial barrier as one predisposing factor in the etiology of CD.
Publish Date 2013-08-13 11:13
Citation S?derman J, Norén E, Christiansson M, Bragde H, Thiébaut R, Hugot JP, Tysk C, O’Morain CA, Gassull M, Finkel Y, Colombel JF, Lémann M, Almer S. Analysis of single nucleotide polymorphisms in the region of CLDN2-MORC4 in relation to inflammatory bowel disease. World J Gastroenterol 2013; 19(30): 4935-4943
URL http://www.wjgnet.com/1007-9327/full/v19/i30/4935.htm
DOI http://dx.doi.org/10.3748/wjg.v19.i30.4935
Full Article (PDF) WJG-19-4935.pdf
Manuscript File 1569-Review.doc
Answering Reviewers 1569-Answering reviewers.pdf
Copyright License Agreement 1569-Copyright assignment.pdf
Peer-review Report 1569-Peer review(s).pdf
Scientific Editor Work List 1569-Scientific editor work list.doc