Publication Name	World Journal of Gastroenterology
Manuscript ID	15811
Country	Norway

Received	2014-12-10 11:28
Peer-Review Started	2014-12-11 13:14
To Make the First Decision	2015-01-22 16:38
Return for Revision	2015-02-02 10:14
Revised	2015-02-09 03:50
Second Decision	2015-03-27 08:17
Accepted by Journal Editor-in-Chief	2015-03-27 18:03
Accepted by Company Editor-in-Chief	2015-04-03 13:38
Articles in Press	2015-04-03 13:53
Publication Fee Transferred
Edit the Manuscript by Language Editor	2015-07-21 19:51
Typeset the Manuscript	2015-08-13 11:42
Publish the Manuscript Online	2015-08-28 17:04

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Case Control Study
Article Title	Reduction in duodenal endocrine cells in irritable bowel syndrome is associated with stem cell abnormalities
Manuscript Source	Unsolicited Manuscript
All Author List	Magdy El-Salhy, Jan Gunnar Hatlebakk and Trygve Hausken
Funding Agency and Grant Number	Funding Agency Grant Number Helse-Vest and Helse-Fonna, Norway
Corresponding Author	Magdy El-Salhy, Professor, Consultant Gastroenterologist, Section for Gastroenterology, Department of Medicine, Stord Hospital, Box 4000, 5409 Stord, Norway. magdy.el-salhy@helse-fonna.no
Key Words	Cholecystokinin; Irritable bowel syndrome; Musashi-1; Neurogenin 3; Secretin; Somatostatin
Core Tip	Musashi 1 (Msi-1) is a marker for both intestinal stem cells and their early progeny, and neurogenin 3 (NEUROG3) is a marker for early intestinal endocrine cell progenitors. The densities of Msi-1 and NEUROG3 cells were reduced in the duodenum of patients with irritable bowel syndrome (IBS), regardless of the subtype, indicating disturbances in both the clonogenic renewal of small intestine stem cells and their proliferation toward endocrine cells. It is most likely that the reduction in the duodenal endocrine cells in patients with IBS is caused by an abnormality in the stem cell clonogenic and proliferation activities.
Publish Date	2015-08-28 17:04
Citation	El-Salhy M, Hatlebakk JG, Hausken T. Reduction in duodenal endocrine cells in irritable bowel syndrome is associated with stem cell abnormalities. World J Gastroenterol 2015; 21(32): 9577-9587
URL	http://www.wjgnet.com/1007-9327/full/v21/i32/9577.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i32.9577

Full Article (PDF)	WJG-21-9577.pdf
Full Article (Word)	WJG-21-9577.doc
Manuscript File	15811-Review.doc
Answering Reviewers	15811-Answering reviewers.pdf
Audio Core Tip	15811-Audio core tip.m4a
Biostatistics Review Certificate	15811-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	15811-Conflict-of-interest statement.pdf
Copyright License Agreement	15811-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	15811-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	15811-Language certificate.pdf
Peer-review Report	15811-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	15811-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	15811-Scientific misconduct check.pdf
Scientific Editor Work List	15811-Scientific editor work list.pdf