Publication Name	World Journal of Gastroenterology
Manuscript ID	15949
Country	Italy

Received	2014-12-18 08:44
Peer-Review Started	2014-12-18 20:22
To Make the First Decision	2015-01-08 16:54
Return for Revision	2015-01-13 08:48
Revised	2015-01-23 00:09
Second Decision	2015-02-11 23:02
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2015-02-13 11:08
Articles in Press	2015-02-13 11:32
Publication Fee Transferred
Edit the Manuscript by Language Editor	2015-03-17 09:57
Typeset the Manuscript	2015-05-21 14:53
Publish the Manuscript Online	2015-06-11 10:11

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Clinical Trials Study
Article Title	Low efficacy of levofloxacin-doxycycline-based third-line triple therapy for Helicobacter pylori eradication in Italy
Manuscript Source	Invited Manuscript
All Author List	Omero Alessandro Paoluzi, Giovanna Del Vecchio Blanco, Emanuela Visconti, Manuela Coppola, Carla Fontana, Marco Favaro and Francesco Pallone
Funding Agency and Grant Number
Corresponding Author	Omero Alessandro Paoluzi, MD, Gastroenterology Unit, Department of Internal Medicine, University Tor Vergata, Viale Oxford 81, 00133 Roma, Italy. omeroalessandro.paoluzi@ptvonline.it
Key Words	Doxycycline; Eradication therapy; Urea breath test; Esomeprazole; Levofloxacin; Helicobacter pylori
Core Tip	Helicobacter pylori eradication therapy should be based on a culture sensitivity test or include antibiotics not already used by patients who failed to respond to two or more previous attempts. Third-line levofloxacin-based triple therapy was demonstrated to be effective in such kind of patients. In the present study, a third-line levofloxacin-doxycycline triple therapy, associated or not with probiotics, was able to eradicate H. pylori infection in about 50% of patients. The low eradication rate achieved by the study regimen was probably due to levofloxacin resistance. Further studies on larger series are needed to confirm the efficacy of levofloxacin-containing regimens in Italy.
Publish Date	2015-06-11 10:11
Citation	Paoluzi OA, Del Vecchio Blanco G, Visconti E, Coppola M, Fontana C, Favaro M, Pallone F. Low efficacy of levofloxacin-doxycycline-based third-line triple therapy for Helicobacter pylori eradication in Italy. World J Gastroenterol 2015; 21(21): 6698-6705
URL	http://www.wjgnet.com/1007-9327/full/v21/i21/6698.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i21.6698

Full Article (PDF)	WJG-21-6698.pdf
Full Article (Word)	WJG-21-6698.doc
Manuscript File	15949-Review.doc
Answering Reviewers	15949-Answering reviewers.pdf
Copyright License Agreement	15949-Copyright assignment.pdf
Peer-review Report	15949-Peer-review(s).pdf
Scientific Misconduct Check	15949-Scientific misconduct check.pdf
Scientific Editor Work List	15949-Scientific editor work list.pdf