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Publication Name World Journal of Gastroenterology
Manuscript ID 1599
Country/Territory United States
Received
2012-12-22 05:42
Peer-Review Started
2012-12-22 15:32
To Make the First Decision
2013-01-09 15:54
Return for Revision
2013-01-10 15:34
Revised
Second Decision
2013-02-07 09:07
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2013-02-07 10:14
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2013-03-31 10:50
Publish the Manuscript Online
2013-04-14 19:05
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Pediatrics
Manuscript Type Autobiography
Article Title Aggressive juvenile polyposis in children with chromosome 10q23 deletion
Manuscript Source Invited Manuscript
All Author List Seth Septer, Lei Zhang, Caitlin E Lawson, Jose Cocjin, Thomas Attard and Holly H Ardinger
Funding Agency and Grant Number
Corresponding Author Dr. Seth Septer, Department of Gastroenterology and Hepatology, Children's Mercy Hospital and Clinics, 2401 Gillham Road, Kansas City, MO 64108, United States. ssepter@cmh.edu
Key Words Polyposis; Genetics; Cancer; Endoscopy pediatric
Core Tip Children with aggressive juvenile polyposis related to microdeletions of chromosome 10q23 and involving PTEN and BMPR1A are rare, however this deletion conveys significant gastrointestinal and extraintestinal risks. Children with this gene mutation are at significant risk for extensive polyposis, early colectomy and gastrointestinal malignancy. This work describes the clinical manifestations associated with these deletions. We also suggest genetic testing strategies for those with juvenile polyps and also propose gastrointestinal surveillance for patients with chromosome 10q23 deletions encompassing PTEN and BMPR1A.
Publish Date 2013-04-14 19:05
Citation Septer S, Zhang L, Lawson CE, Cocjin J, Attard T, Ardinger HH. Aggressive juvenile polyposis in children with chromosome 10q23 deletion. World J Gastroenterol 2013; 19(14): 2286-2292
URL http://www.wjgnet.com/1007-9327/full/v19/i14/2286.htm
DOI http://dx.doi.org/10.3748/wjg.v19.i14.2286
Full Article (PDF) WJG-19-2286.pdf
Manuscript File 1599-Review.docx
Answering Reviewers 1599-Answering reviewers.pdf
Copyright License Agreement 1599-Copyright assignment.pdf
Peer-review Report 1599-Peer reviews.docx
Scientific Editor Work List 1599-Scientific editor work list.doc