| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
|
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
|
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Observational Study |
| Article Title |
Locoregional therapy and systemic cetuximab to treat colorectal liver metastases
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Giammaria Fiorentini, Camillo Aliberti, Donatella Sarti, Paolo Coschiera, Massimo Tilli, Luca Mulazzani, Paolo Giordani, Francesco Graziano, Alfonso Marqués Gonzalez, Raul García Marcos, Fernando Gómez Mugnoz, Maurizio Cantore, Stefano Ricci, Vincenzo Catalano and Andrea Mambrini |
| Funding Agency and Grant Number |
|
| Corresponding Author |
Dr. Giammaria Fiorentini, Oncology Unit, Azienda Ospedaliera “Ospedali Riuniti Marche Nord”, San Salvatore Hospital, Via Lombroso 1, 61122 Pesaro,
Italy. g.fiorentini@alice.it
|
| Key Words |
Cetuximab; Irinotecan-loaded drug-eluting beads; Hepatic metastases; Chemoembolization; Colon rectal tumor; Irinotecan |
| Core Tip |
Irinotecan-loaded drug-eluting beads (DEBIRI) has shown manageable toxicities and favorable response rates for unresectable colorectal liver metastasis (CRC-LM). This study is the first in the world investigating effectiveness and toxicity of the association DEBIRI and cetuximab (DEBIRITUX) as second line therapy of CRC-LM. Forty cases were enrolled. The overall response rate (ORR) was 50%. Most frequent side effects were: post-embolization syndrome, diarrhea, skin rushes and asthenia. The group of patients with wild type KRas had ORR significantly higher than mutant Kras. The median progression free survival was 9.8 mo and overall survival was 20.4 mo. DEBIRITUX regimen seems effective and safe after first line chemotherapy for CRC-LM.
|
| Publish Date |
2015-06-19 15:00 |
| Citation |
Fiorentini G, Aliberti C, Sarti D, Coschiera P, Tilli M, Mulazzani L, Giordani P, Graziano F, Marqués Gonzalez A, García Marcos R, Gómez Mugnoz F, Cantore M, Ricci S, Catalano V, Mambrini A. Locoregional therapy and systemic cetuximab to treat colorectal liver metastases. World J Gastrointest Oncol 2015; 7(6): 47-54 |
| URL |
http://www.wjgnet.com/1948-5204/full/v7/i6/47.htm |
| DOI |
http://dx.doi.org/10.4251/wjgo.v7.i6.47 |
