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6/29/2015 4:40:00 PM | Browse: 1159 | Download: 1527
Publication Name World Journal of Gastroenterology
Manuscript ID 16550
Country/Territory Japan
Received
2015-01-22 21:00
Peer-Review Started
2015-01-24 08:34
To Make the First Decision
2015-02-10 15:30
Return for Revision
2015-02-12 14:32
Revised
2015-02-24 08:26
Second Decision
2015-04-22 08:03
Accepted by Journal Editor-in-Chief
2015-04-22 20:35
Accepted by Company Editor-in-Chief
2015-05-04 18:13
Articles in Press
2015-05-04 18:13
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-06-15 10:11
Publish the Manuscript Online
2015-06-29 16:33
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Nanoscience & Nanotechnology
Manuscript Type Topic Highlights
Article Title Applications of human hepatitis B virus preS domain in bio- and nanotechnology
Manuscript Source Invited Manuscript
All Author List Riki Toita, Takahito Kawano, Jeong-Hun Kang and Masaharu Murata
Funding Agency and Grant Number
Funding Agency Grant Number
Health Labour Sciences Research Grant
Health Labour Sciences Research Grant
Scientific Research 24300172
Scientific Research for Young-Scientists 25750176
Fukuoka Foundation for Sound Health Cancer Research Fund
Corresponding Author Masaharu Murata, Professor, Department of Advanced Medical Initiatives, Faculty of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. m-murata@dem.med.kyushu-u.ac.jp
Key Words Hepatitis B virus; Hepatocyte; delivery system; Vaccine; Hepatitis B surface antigen; Diagnosis
Core Tip The hepatitis B surface antigen (HBsAg) of human hepatitis B virus (HBV) contains the large (L), middle (M), and small (S) surface proteins. The L protein consists of the S protein, preS1, and preS2. In HBsAg, the preS domain (preS1 + preS2) plays a key role in the infection of hepatocytic cells by HBV and has several immunogenic epitopes. Therefore, the preS domain can act as a diagnostic or therapeutic target or as material for developing inhibitors of HBV infection, HBV vaccines, diagnostic tools for HBV infection, and hepatocyte-targeting delivery systems for diagnostic or therapeutic molecules.
Publish Date 2015-06-29 16:33
Citation Toita R, Kawano T, Kang JH, Murata M. Applications of human hepatitis B virus preS domain in bio- and nanotechnology. World J Gastroenterol 2015; 21(24): 7400-7411
URL http://www.wjgnet.com/1007-9327/full/v21/i24/7400.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i24.7400
Full Article (PDF) WJG-21-7400.pdf
Full Article (Word) WJG-21-7400.doc
Manuscript File 16550-Review.docx
Answering Reviewers 16550-Answering reviewers.pdf
Audio Core Tip 16550-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 16550-Conflict-of-interest statement.pdf
Copyright License Agreement 16550-Copyright assignment.pdf
Peer-review Report 16550-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 16550-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 16550-Scientific misconduct check.pdf
Scientific Editor Work List 16550-Scientific editor work list.pdf