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6/29/2015 4:40:00 PM | Browse: 949 | Download: 1947
Publication Name World Journal of Gastroenterology
Manuscript ID 16558
Country/Territory Italy
Received
2015-01-23 08:46
Peer-Review Started
2015-01-24 11:07
To Make the First Decision
2015-03-10 19:50
Return for Revision
2015-03-17 11:30
Revised
2015-03-31 18:27
Second Decision
2015-05-04 08:30
Accepted by Journal Editor-in-Chief
2015-05-07 23:18
Accepted by Company Editor-in-Chief
2015-05-21 17:40
Articles in Press
2015-05-21 17:41
Publication Fee Transferred
Edit the Manuscript by Language Editor
2015-05-22 19:32
Typeset the Manuscript
2015-06-12 13:42
Publish the Manuscript Online
2015-06-29 16:33
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Prospective Study
Article Title Evolution of nonspecific duodenal lymphocytosis over 2 years of follow-up
Manuscript Source Invited Manuscript
All Author List Giuseppe Losurdo, Domenico Piscitelli, Antonio Giangaspero, Mariabeatrice Principi, Francesca Buffelli, Floriana Giorgio, Lucia Montenegro, Claudia Sorrentino, Annacinzia Amoruso, Enzo Ierardi and Alfredo Di Leo
Funding Agency and Grant Number
Corresponding Author Enzo Ierardi, Professor, Gastroenterology Section, Department of Emergency and Organ Transplantation, University of Bari, Policlinico, Piazza Giulio Cesare, 70124 Bari, Italy. ierardi.enzo@gmail.com
Key Words Duodenal lymphocytosis; Celiac disease; Gluten sensitivity; Seronegative celiac disease; Intraepithelial lymphocytes; Immunohistochemistry
Core Tip Duodenal lymphocytosis may pose a diagnostic challenge since it could be associated with different pathological conditions, which may or may not be related to gluten. In the present study, we demonstrated that during 2 years of follow-up of 85 patients with duodenal lymphocytosis, 27% developed celiac disease and 22% had a clinical diagnosis of gluten sensitivity; the remaining patients were affected by non-gluten-related conditions. At multivariate analysis, the haplotype DQ2/8 and the density of the intraepithelial CD3 lymphocyte infiltrate were the best predictors of the future development of gluten-related disorders.
Publish Date 2015-06-29 16:33
Citation Losurdo G, Piscitelli D, Giangaspero A, Principi M, Buffelli F, Giorgio F, Montenegro L, Sorrentino C, Amoruso A, Ierardi E, Di Leo A. Evolution of nonspecific duodenal lymphocytosis over 2 years of follow-up. World J Gastroenterol 2015; 21(24): 7545-7552
URL http://www.wjgnet.com/1007-9327/full/v21/i24/7545.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i24.7545
Full Article (PDF) WJG-21-7545.pdf
Full Article (Word) WJG-21-7545.doc
Manuscript File 16558-Review.doc
Answering Reviewers 16558-Answering reviewers.pdf
Audio Core Tip 16558-Audio core tip.mp3
Biostatistics Review Certificate 16558-Biostatistics statement.pdf
Clinical Trial Registration Statement 16558-Clinical trial registration statement.pdf
Conflict-of-Interest Disclosure Form 16558-Conflict-of-interest statement.pdf
Copyright License Agreement 16558-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s) 16558-Clinical trial registration statement.pdf
Institutional Review Board Approval Form or Document 16558-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 16558-Language certificate.pdf
Peer-review Report 16558-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 16558-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 16558-Scientific misconduct check.pdf
Scientific Editor Work List 16558-Scientific editor work list.pdf