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4/28/2015 10:28:00 AM | Browse: 978 | Download: 1275
Publication Name World Journal of Dermatology
Manuscript ID 16679
Country/Territory Taiwan
Received
2015-01-27 08:45
Peer-Review Started
2015-01-28 11:42
To Make the First Decision
2015-03-06 10:30
Return for Revision
2015-03-11 12:22
Revised
2015-03-16 00:19
Second Decision
2015-04-01 15:03
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2015-04-09 16:52
Articles in Press
2015-04-09 16:52
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-04-15 08:41
Publish the Manuscript Online
2015-04-28 10:28
ISSN 2218-6190 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.¬¬
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Dermatology
Manuscript Type Editorial
Article Title Mycosis fungoides and Sézary syndrome: Role of chemokines and chemokine receptors
Manuscript Source Invited Manuscript
All Author List Stephen Chu-Sung Hu
Funding Agency and Grant Number
Corresponding Author Stephen Chu-Sung Hu, MBBS, M.Phil, Department of Dermatology, Kaohsiung Medical University Hospital, No. 100, Tzyou 1st Road, Kaohsiung 807, Taiwan. stephenhu30@hotmail.com
Key Words Mycosis fungoides; Sézary syndrome; Skin-homing; Chemokines; Chemokine receptors
Core Tip Mycosis fungoides and Sézary syndrome are characterized by a clonal expansion of malignant CD4+ T lymphocytes with skin-homing properties. Currently, treatment options for mycosis fungoides and Sézary syndrome are limited. The lack of effective targeted therapy results in part from the poor understanding regarding the pathophysiology of these diseases. Recently, a number of chemokines and chemokine receptors have been found to contribute to the pathogenesis of mycosis fungoides and Sézary syndrome, including the CC chemokine receptor 4 (CCR4)/chemokine (C-C motif) ligand 17 (CCL17), CCR10/CCL27, C-X-C chemokine receptor type 4/chemokine (C-X-C Motif) ligand 12 and CCR7/CCL21 axes. Therefore, these chemokines and chemokine receptors may be potentially useful targets for the treatment of these lymphomas in the future.
Publish Date 2015-04-28 10:28
Citation Hu SC. Mycosis fungoides and Sézary syndrome: Role of chemokines and chemokine receptors. World J Dermatol 2015; 4(2): 69-79
URL http://www.wjgnet.com/2218-6190/full/v4/i2/69.htm
DOI http://dx.doi.org/10.5314/wjd.v4.i2.69
Full Article (PDF) WJD-4-69.pdf
Full Article (Word) WJD-4-69.doc
Manuscript File 16679-Review.doc
Answering Reviewers 16679-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form 16679-Conflict-of-interest statement.pdf
Copyright License Agreement 16679-Copyright assignment.pdf
Peer-review Report 16679-Peer-review(s).pdf
Scientific Misconduct Check 16679-Scientific misconduct check.pdf
Scientific Editor Work List 16679-Scientific editor work list.pdf