Publication Name	World Journal of Gastroenterology
Manuscript ID	16738
Country	Italy

Received	2015-01-28 08:34
Peer-Review Started	2015-01-28 17:30
To Make the First Decision	2015-03-10 17:49
Return for Revision	2015-03-12 10:42
Revised	2015-03-25 21:59
Second Decision	2015-04-23 08:22
Accepted by Journal Editor-in-Chief	2015-04-23 09:41
Accepted by Company Editor-in-Chief	2015-05-04 17:31
Articles in Press	2015-05-04 17:32
Publication Fee Transferred
Edit the Manuscript by Language Editor	2015-06-08 16:28
Typeset the Manuscript	2015-07-02 09:32
Publish the Manuscript Online	2015-07-14 12:17

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Surgery
Manuscript Type	Editorial
Article Title	Multimodal treatment of gastric cancer in the west: Where are we going?
Manuscript Source	Invited Manuscript
All Author List	Daniele Marrelli, Karol Polom, Giovanni de Manzoni, Paolo Morgagni, Gian Luca Baiocchi and Franco Roviello
Funding Agency and Grant Number
Corresponding Author	Daniele Marrelli, MD, Associate Professor, Department of Medicine, Surgery and Neurosciences, University of Siena, 55 Via Banchi di Sotto, 53100 Siena, Italy. daniele.marrelli@unisi.it
Key Words	Epidemiology; Hyperthermic intraperitoneal chemotherapy; Chemotherapy; Radiotherapy; Gastric cancer; Targeted therapy
Core Tip	In advanced gastric cancer (GC), multimodal treatment is currently an option in the west. Adequate surgery and extended lymphadenectomy, together with modern chemotherapy, radiotherapy, targeted therapies, and a combination of all could possibly improve survival in advanced GC. A tailored multimodal approach is strictly necessary in the light of treatment results and recent epidemiological trends, which indicate a relative increase of more aggressive forms, such as proximal location and diffuse Lauren histotype in the west. The main ongoing and completed clinical trials regarding multimodal approach to GC have been reviewed, and an original tailored multimodal protocol to non-cardia GC has been proposed.
Publish Date	2015-07-14 12:17
Citation	Marrelli D, Polom K, de Manzoni G, Morgagni P, Baiocchi GL, Roviello F. Multimodal treatment of gastric cancer in the west: Where are we going? World J Gastroenterol 2015; 21(26): 7954-7969
URL	http://www.wjgnet.com/1007-9327/full/v21/i26/7954.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i26.7954

Full Article (PDF)	WJG-21-7954.pdf
Full Article (Word)	WJG-21-7954.doc
Manuscript File	16738-Review.docx
Answering Reviewers	16738-Answering reviewers.pdf
Audio Core Tip	16738-Audio core tip.wav
Conflict-of-Interest Disclosure Form	16738-Conflict of interest statement.pdf
Copyright License Agreement	16738-Copyright assignment.pdf
Peer-review Report	16738-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	16738-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	16738-Scientific misconduct check.pdf
Scientific Editor Work List	16738-Scientific editor work list.pdf