BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
11/11/2015 1:33:00 PM | Browse: 858 | Download: 1282
Publication Name World Journal of Gastroenterology
Manuscript ID 16751
Country/Territory Taiwan
Received
2015-01-29 09:59
Peer-Review Started
2015-01-29 21:59
To Make the First Decision
2015-04-13 15:52
Return for Revision
2015-04-14 10:33
Revised
2015-04-27 13:43
Second Decision
2015-09-28 16:02
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2015-09-30 09:58
Articles in Press
2015-09-30 09:58
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-10-20 10:29
Publish the Manuscript Online
2015-11-11 13:34
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Editorial
Article Title Hepatic immune tolerance induced by hepatic stellate cells
Manuscript Source Invited Manuscript
All Author List Ching-Chuan Hsieh, Chien-Hui Hung, Lina Lu and Shiguang Qian
Funding Agency and Grant Number
Funding Agency Grant Number
National Science Council NSC 101-2314-B-182A-040-MY2
National Science Council CMRPG6A0523
Corresponding Author Ching-Chuan Hsieh, MD, Department of Surgery, Chang Gung Memorial Hospital at Chiayi, 6 Sec. West Chia-Pu Road, Pu-Zi City, Chiayi 613, Taiwan. jeffrey570404@gmail.com
Key Words Hepatic stellate cells; Myeloid-derived suppressor cells; Hepatic tolerance; Immunotherapy
Core Tip The liver is an immune privileged organ that contains cells exhibiting powerful immune regulatory activity. Hepatic stellate cells (HpSCs) possess weak antigen-presenting ability and function as immunological bystander cells in the regulation of the immune response by the way of induction of effector T cell apoptosis and the generation of myeloid-derived suppressor cells and regulatory T cells. The combination of these mechanisms indicates that HpSCs are a potent immunoregulatory entity capable of modulating immune responses in the liver. HpSCs can orchestrate both innate immunity and adaptive immunity to build a negative immune network that leads to immune tolerance. Further understanding of hepatic immune tolerance will provide the basis for developing new immunotherapies that target transplant rejection, chronic viral infection and cancer.
Publish Date 2015-11-11 13:34
Citation Hsieh CC, Hung CH, Lu L, Qian S. Hepatic immune tolerance induced by hepatic stellate cells. World J Gastroenterol 2015; 21(42): 11887-11892
URL http://www.wjgnet.com/1007-9327/full/v21/i42/11887.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i42.11887
Full Article (PDF) WJG-21-11887.pdf
Full Article (Word) WJG-21-11887.doc
Manuscript File 16751-Review.docx
Answering Reviewers 16751-Answering reviewers.pdf
Audio Core Tip 16751-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 16751-Conflict-of-interest statement.pdf
Copyright License Agreement 16751-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 16751-Language certificate.pdf
Peer-review Report 16751-Peer-review(s).pdf
Scientific Misconduct Check 16751-Scientific misconduct check.pdf
Scientific Editor Work List 16751-Scientific editor work list.pdf