Publication Name	World Journal of Gastroenterology
Manuscript ID	16758
Country	Japan

Received	2015-01-29 09:43
Peer-Review Started	2015-01-29 21:44
To Make the First Decision	2015-03-26 18:11
Return for Revision	2015-03-30 13:45
Revised	2015-04-09 18:47
Second Decision	2015-04-27 10:22
Accepted by Journal Editor-in-Chief	2015-04-28 15:23
Accepted by Company Editor-in-Chief	2015-05-04 17:32
Articles in Press	2015-05-04 17:32
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-06-02 10:02
Publish the Manuscript Online	2015-06-20 17:38

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Novel therapeutic approaches for hepatitis B virus covalently closed circular DNA
Manuscript Source	Invited Manuscript
All Author List	Motoko Ohno, Motoyuki Otsuka, Takahiro Kishikawa, Takeshi Yoshikawa, Akemi Takata and Kazuhiko Koike
Funding Agency and Grant Number
Corresponding Author	Motoyuki Otsuka, MD, Department of Gastroenterology, Graduate School of Medicine, the University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. otsukamo-tky@umin.ac.jp
Key Words	Hepatitis B virus; Covalently closed circular HBV DNA; Genome editing
Core Tip	Hepatitis B virus (HBV) infection is a global health problem. Because current therapeutic approaches do not eliminate HBV nuclear covalently closed circular DNA (cccDNA), novel therapeutics to target cccDNA are needed to eradicate HBV infection. Genome editing technologies are expected to be promising therapeutic options against HBV cccDNA. In particular, the clustered regularly interspaced short palindromic repeats/Cas9 system is an easily customizable sequence-specific nuclease with great flexibility and may be the most feasible approach to target HBV cccDNA, as further research studies develop more effective protocols.
Publish Date	2015-06-20 17:38
Citation	Ohno M, Otsuka M, Kishikawa T, Yoshikawa T, Takata A, Koike K. Novel therapeutic approaches for hepatitis B virus covalently closed circular DNA. World J Gastroenterol 2015; 21(23): 7084-7088
URL	http://www.wjgnet.com/1007-9327/full/v21/i23/7084.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i23.7084

Full Article (PDF)	WJG-21-7084.pdf
Full Article (Word)	WJG-21-7084.doc
Manuscript File	16758-Review.doc
Answering Reviewers	16758-Answering reviewers.pdf
Audio Core Tip	16758-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	16758-Conflict-of-interest statement.pdf
Copyright License Agreement	16758-Copyright agreement.pdf
Non-Native Speakers of English Editing Certificate	16758-Language certificate.pdf
Peer-review Report	16758-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	16758-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	16758-Scientific misconduct check.pdf
Scientific Editor Work List	16758-Scientific editor work list.pdf