| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Autobiography |
| Article Title |
Predominant mucosal IL-8 mRNA expression in non-cagA Thais is risk for gastric cancer
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Sirikan Yamada, Shunji Kato, Takeshi Matsuhisa, Luksana Makonkawkeyoon, Masaru Yoshida, Thiraphat Chakrabandhu, Nirush Lertprasertsuk, Pawit Suttharat, Bandhuphat Chakrabandhu, Shin Nishiumi, Wilaiwan Chongraksut and Takeshi Azuma |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| JSPS Ronpaku (Dissertation PhD) program award by Japan Society for the Promotion of Scince and in collaboration with Kobe University School of Medicine, Kobe, Japan |
NRCT 10726 |
| JSPS Asian CORE Program 2012, Nippon Medical School |
|
| Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand (in part) |
|
|
| Corresponding Author |
Sirikan Yamada, MD, Division of Gastrointestinal Surgery and Endoscopy, Department of Surgery, Chiang Mai University, 239 Huay Kaew Road, Tambon Suthep, Muang District, Chiang Mai 50200, Thailand. siyamada@yahoo.com
|
| Key Words |
Gastric cancer; CagA mutation; Interleukine-8 mRNA expression; Helicobacter pylori; Pepsinogen Ⅰ/Ⅱ ratio |
| Core Tip |
A high level of interleukine-8 (IL-8) mRNA expression was detected in more than eighty percent of Thai gastric cancer patients and nearly two fold in the normal Thai population. The majority of northern Thai gastric cancer patients who had negative cagA gene Helicobacter pylori infection even with or without its mutation, still have a high IL-8 mRNA expression level. The pathogenesis of Thai gastric cancer may primarily involve another gate-way besides the bacterial factor. The results show that there is a predominantly cancer inflammation state regulated by IL-8 mRNA expression level that can be detected in Thai gastric cancer patients. |
| Publish Date |
2013-05-20 14:33 |
| Citation |
Yamada S, Kato S, Matsuhisa T, Makonkawkeyoon L, Yoshida M, Chakrabandhu T, Lertprasertsuk N, Suttharat P, Chakrabandhu B, Nishiumi S, Chongraksut W, Azuma T. Predominant mucosal IL-8 mRNA expression in non-cagA Thais is risk for gastric cancer. World J Gastroenterol 2013; 19(19): 2941-2949 |
| URL |
http://www.wjgnet.com/1007-9327/full/v19/i19/2941.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v19.i19.2941 |
