Publication Name	World Journal of Critical Care Medicine
Manuscript ID	17038
Country

Received	2015-02-09 08:32
Peer-Review Started	2015-02-09 17:08
To Make the First Decision	2015-04-10 16:41
Return for Revision	2015-04-15 10:04
Revised	2015-04-29 16:07
Second Decision	2015-05-15 16:30
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2015-05-28 18:17
Articles in Press	2015-05-28 18:18
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-07-27 17:18
Publish the Manuscript Online	2015-08-17 18:00

ISSN	2220-3141(online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Critical Care Medicine
Manuscript Type	Review
Article Title	Brain-lung crosstalk: Implications for neurocritical care patients
Manuscript Source	Invited Manuscript
All Author List	Ségolène Mrozek, Jean-Michel Constantin and Thomas Geeraerts
Funding Agency and Grant Number
Corresponding Author	Ségolène Mrozek, MD, Anesthesiology and Critical Care Department, Equipe d’accueil “Modélisation de l’agression tissulaire et nociceptive”, University Hospital of Toulouse, University Toulouse 3 Paul Sabatier, 31000 Toulouse, France. mrozek.s@chu-toulouse.fr
Key Words	Brain-lung crosstalk; Brain injury; Lung injury; Protective ventilation; Double hit model
Core Tip	Brain lung crosstalk is a complex interaction from the brain to the lung but also from the lung to the brain. Intensivists are often fearful to use some parts of protective ventilation in patients with brain injuries but if correctly applied, mechanical ventilation could have beneficial effect on brain oxygenation, even if positive end-expiratory pressure and recruitment maneuvers are used. This review aims to describe the epidemiology and pathophysiology of lung injuries in brain-injured patients, but also the impact of different modalities of mechanical ventilation on the brain in the context of acute brain injury.
Publish Date	2015-08-17 18:00
Citation	Mrozek S, Constantin JM, Geeraerts T. Brain-lung crosstalk: Implications for neurocritical care patients. World J Crit Care Med 2015; 4(3): 163-178
URL	http://www.wjgnet.com/2220-3141/full/v4/i3/163.htm
DOI	http://dx.doi.org/10.5492/wjccm.v4.i3.163

Full Article (PDF)	WJCCM-4-163.pdf
Full Article (Word)	WJCCM-4-163.doc
Manuscript File	17038-Review .docx
Answering Reviewers	17038-Answering reviewers.pdf
Audio Core Tip	17038-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	17038-Conflict-of-interest statement.pdf
Copyright License Agreement	17038-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	17038-Language certificate.pdf
Peer-review Report	17038-Peer-review(s).pdf
Scientific Misconduct Check	17038-Scientific misconduct check.pdf
Scientific Editor Work List	17038-Scientific editor work list.pdf