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Publication Name World Journal of Gastroenterology
Manuscript ID 1723
Country/Territory China
Received
2012-12-31 08:49
Peer-Review Started
2012-12-31 11:31
To Make the First Decision
2013-02-01 21:46
Return for Revision
2013-02-17 11:23
Revised
2013-02-21 19:23
Second Decision
2013-04-03 15:27
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2013-04-04 04:13
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2013-06-04 17:40
Publish the Manuscript Online
2013-06-20 16:34
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Autobiography
Article Title Bone-marrow mesenchymal stem cells reduce rat intestinal ischemia-reperfusion injury, ZO-1 downregulation and tight junction disruption via a TNF-α-regulated mechanism
Manuscript Source Invited Manuscript
All Author List Zhong-Yang Shen, Jing Zhang, Hong-Li Song and Wei-Ping Zheng
Funding Agency and Grant Number
Funding Agency Grant Number
Natural Science Foundation of China 81270528
Natural Science Foundation of Tianjin 08JCYBJC08400
Natural Science Foundation of Tianjin 11JCZDJC27800
Natural Science Foundation of Tianjin 12JCZDJC25200
Technology Foundation of Health Bureau in Tianjin 2011KY11
Corresponding Author Hong-Li Song, MD, PhD, Professor of Medicine, Department of Organ Transplantation, Tianjin First Central Hospital, No. 24 Fukang Road, Nankai District, Tianjin 300192, China. hlsong26@163.com
Key Words Bone marrow mesenchymal stem cells; Zona occludens 1; Ischemia-reperfusion injury; Intestinal mucosa; Tumor necrosis factor-α
Core Tip Intestinal ischemia/reperfusion (I/R) injury is clinically important. Bone-marrow mesenchymal stem cells (BM MSCs) can protect against I/R injury; however, the mechanism is unclear. This study demonstrates that submucosal infusion of BM MSCs decreased intestinal permeability and preserved intestinal mechanical barrier function after I/R injury in rats, via a mechanism linked to reduced serum tumor necrosis factor (TNF)-α levels and increased expression of the intestinal tight junction protein zona occludens 1. Altered serum TNF-α levels play an important role in the ability of BM MSCs to protect against intestinal I/R injury.
Publish Date 2013-06-20 16:34
Citation Shen ZY, Zhang J, Song HL, Zheng WP. Bone-marrow mesenchymal stem cells reduce rat intestinal ischemia-reperfusion injury, ZO-1 downregulation and tight junction disruption via a TNF-α-regulated mechanism. World J Gastroenterol 2013; 19(23): 3583-3595
URL http://www.wjgnet.com/1007-9327/full/v19/i23/3583.htm
DOI http://dx.doi.org/10.3748/wjg.v19.i23.3583
Full Article (PDF) WJG-19-3583.pdf
Manuscript File 1723-Review.doc
Answering Reviewers 1723-Answering Reviewers.doc
Copyright License Agreement 1723-Copyright Assignment.pdf
Non-Native Speakers of English Editing Certificate 1723-Language certificate.pdf
Peer-review Report 1723-Peer review(s).pdf
Scientific Editor Work List 1723-Scientific editor work list.doc