BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
8/26/2015 11:07:00 AM | Browse: 870 | Download: 1012
Publication Name World Journal of Biological Chemistry
Manuscript ID 17345
Country/Territory United States
Received
2015-03-03 08:32
Peer-Review Started
2015-03-04 20:33
To Make the First Decision
2015-05-13 19:16
Return for Revision
2015-05-19 16:26
Revised
2015-06-03 11:11
Second Decision
2015-07-06 08:36
Accepted by Journal Editor-in-Chief
2015-07-06 18:57
Accepted by Company Editor-in-Chief
2015-08-03 15:49
Articles in Press
2015-08-03 15:50
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-08-07 16:03
Publish the Manuscript Online
2015-08-26 11:07
ISSN 1949-8454 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Biochemistry & Molecular Biology
Manuscript Type Editorial
Article Title Mechanism of DNA damage tolerance
Manuscript Source Invited Manuscript
All Author List Xin Bi
Funding Agency and Grant Number
Funding Agency Grant Number
United States National Science Foundation MCB-1158008
Corresponding Author Xin Bi, PhD, Professor, Department of Biology, University of Rochester, Rochester, NY 14627, United States. xin.bi@rochester.edu
Key Words DNA damage tolerance; Template switching; DNA damage bypass; DNA replication; Replicative stress; Translesion synthesis; Ubiquitination; Sumoylation
Core Tip DNA damage may compromise genome in?tegrity and lead to cell death. Cells have evolved a variety of processes to respond to DNA damage including damage repair and tolerance mechanisms. The DNA damage tolerance (DDT) pathway promotes the bypass of single-stranded DNA lesions encountered by DNA polymerases during DNA replication. This prevents the stalling of DNA replication. Two mechanistically distinct DDT branches, translesion synthesis and template switching have been characterized. However, our current understanding of DDT is far from complete and that of template switching is especially sketchy. This editorial focuses on recently identified components and regulators of DDT.
Publish Date 2015-08-26 11:07
Citation Bi X. Mechanism of DNA damage tolerance. World J Biol Chem 2015; 6(3): 48-56
URL http://www.wjgnet.com/1949-8454/full/v6/i3/48.htm
DOI http://dx.doi.org/10.4331/wjbc.v6.i3.48
Full Article (PDF) WJBC-6-48.pdf
Full Article (Word) WJBC-6-48.doc
Manuscript File 17345-Review.docx
Answering Reviewers 17345-Answering reviewers.pdf
Audio Core Tip 17345-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 17345-Conflict-of-interest statement.pdf
Copyright License Agreement 17345-Copyright assignment.pdf
Peer-review Report 17345-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 17345-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 17345-Scientific misconduct check.pdf
Scientific Editor Work List 17345-Scientific editor work list.pdf