Publication Name	World Journal of Hepatology
Manuscript ID	17674
Country	Japan

Received	2015-03-18 15:57
Peer-Review Started	2015-03-18 21:29
To Make the First Decision	2015-04-23 14:44
Return for Revision	2015-04-28 19:43
Revised	2015-05-07 13:34
Second Decision	2015-08-10 08:23
Accepted by Journal Editor-in-Chief	2015-08-10 15:06
Accepted by Company Editor-in-Chief	2015-09-07 08:21
Articles in Press	2015-09-07 08:21
Publication Fee Transferred
Edit the Manuscript by Language Editor	2015-09-09 16:26
Typeset the Manuscript	2015-09-24 10:28
Publish the Manuscript Online	2015-10-19 16:02

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Contribution of the toxic advanced glycation end-products-receptor axis in nonalcoholic steatohepatitis-related hepatocellular carcinoma
Manuscript Source	Invited Manuscript
All Author List	Jun-ichi Takino, Kentaro Nagamine, Takamitsu Hori, Akiko Sakasai-Sakai and Masayoshi Takeuchi
Funding Agency and Grant Number	Funding Agency Grant Number Japan Society for the Promotion of Science (JSPS) KAKENHI 22300264 Japan Society for the Promotion of Science (JSPS) KAKENHI 25282029 (to Takeuchi M) Ministry of Education, Culture, Sports, Science Technology (MEXT), Regional Innovation Strategy Support Program to Takeuchi M Kanazawa Medical University SR2012-04
Corresponding Author	Masayoshi Takeuchi, PhD, Department of Advanced Medicine, Medical Research Institute, Kanazawa Medical University, 1-1 Daigaku, Uchinada-machi, Kahoku, Ishikawa 920-0293, Japan. takeuchi@kanazawa-med.ac.jp
Key Words	Hepatocellular carcinoma; Nonalcoholic steatohepatitis; Advanced glycation end-products; Toxic advanced glycation end-products; Receptor for advanced glycation end-products; Hepatic stellate cells
Core Tip	Expression of the receptor for advanced glycation end-products (RAGE), which is a multi-ligand cell surface receptor, is correlated with the poor therapeutic outcomes and malignancy of hepatocellular carcinoma (HCC). The synthesis of toxic advanced glycation end-products (TAGE), ligands of RAGE, is increased in nonalcoholic steatohepatitis (NASH) as well as in NASH-related HCC. Interactions between TAGE and RAGE induce oxidative stress, which may, in turn, lead to adverse effects in tumor cells and hepatic stellate cells during NASH or NASH-related HCC progression. Therefore, these findings prompted us to suggest that the TAGE-RAGE axis may be a treatment target in NASH-related HCC.
Publish Date	2015-10-19 16:02
Citation	Takino J, Nagamine K, Hori T, Sakasai-Sakai A, Takeuchi M. Contribution of the toxic advanced glycation end-products-receptor axis in nonalcoholic steatohepatitis-related hepatocellular carcinoma. World J Hepatol 2015; 7(23): 2459-2469
URL	http://www.wjgnet.com/1948-5182/full/v7/i23/2459.htm
DOI	http://dx.doi.org/10.4254/wjh.v7.i23.2459

Full Article (PDF)	WJH-7-2459.pdf
Full Article (Word)	WJH-7-2459.doc
Manuscript File	17674-Review.docx
Answering Reviewers	17674-Answering reviewers.pdf
Audio Core Tip	17674-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	17674-Conflict-of-interest statement.pdf
Copyright License Agreement	17674-Copyright assignment.pdf
Peer-review Report	17674-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	17674-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	17674-Scientific misconduct check.pdf
Scientific Editor Work List	17674-Scientific editor work list.pdf