Publication Name	World Journal of Gastroenterology
Manuscript ID	17789
Country	Japan

Received	2015-03-25 12:10
Peer-Review Started	2015-03-27 08:24
To Make the First Decision	2015-04-24 19:21
Return for Revision	2015-04-30 11:07
Revised	2015-05-08 13:01
Second Decision	2015-08-19 14:45
Accepted by Journal Editor-in-Chief	2015-08-20 07:23
Accepted by Company Editor-in-Chief	2015-09-02 15:22
Articles in Press	2015-09-02 15:23
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-09-10 14:59
Publish the Manuscript Online	2015-09-28 18:06

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Genetic and epigenetic aspects of initiation and progression of hepatocellular carcinoma
Manuscript Source	Invited Manuscript
All Author List	Mitsuro Kanda, Hiroyuki Sugimoto and Yasuhiro Kodera
Funding Agency and Grant Number
Corresponding Author	Mitsuro Kanda, MD, PhD, Department of Gastroenterological Surgery (Surgery Ⅱ), Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan. m-kanda@med.nagoya-u.ac.jp
Key Words	Hepatocellular carcinoma; Oncogene; Tumor suppressor gene; MicroRNA; DNA methylation
Core Tip	Despite the large number of studies dedicated to the molecular diagnosis of hepatocellular carcinoma (HCC), highly sensitive biomarkers of the initiation and progression of HCC still need to be identified. At the same time, the development of novel molecular targeting agents that can surpass the effect of the multikinase inhibitor sorafenib is much-anticipated. This review aimed to update our knowledge of genetic and epigenetic aspects of HCC by providing an overview of novel HCC-related genes and microRNAs as candidates for use as diagnostic and therapeutic targets in HCC.
Publish Date	2015-09-28 18:06
Citation	Kanda M, Sugimoto H, Kodera Y. Genetic and epigenetic aspects of initiation and progression of hepatocellular carcinoma. World J Gastroenterol 2015; 21(37): 10584-10597
URL	http://www.wjgnet.com/1007-9327/full/v21/i37/10584.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i37.10584

Full Article (PDF)	WJG-21-10584.pdf
Full Article (Word)	WJG-21-10584.doc
Manuscript File	17789-Review.docx
Answering Reviewers	17789-Answering reviewers.pdf
Audio Core Tip	17789-Audio core tip.wav
Conflict-of-Interest Disclosure Form	17789-Conflict-of-interest statement.pdf
Copyright License Agreement	17789-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	17789-Language certificate.pdf
Peer-review Report	17789-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	17789-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	17789-Scientific misconduct check.pdf
Scientific Editor Work List	17789-Scientific editor work list.pdf