| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Allergy |
| Manuscript Type |
Basic Study |
| Article Title |
N-acetylcysteine modulates angiogenesis and vasodilation in stomach such as DNA damage in blood of portal hypertensive rats
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Francielli Licks, Renata Minuzzo Hartmann, Camila Marques, Elizângela Schemitt, Josieli Raskopf Colares, Mariana do Couto Soares, Juliana Reys, Camila Fisher, Juliana da Silva and Norma Possa Marroni |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Laboratory of Experimental Hepatology and Gastroenterology, Universidade Federal do Rio Grande do Sul |
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| Oxidative Stress and Antioxidants Laboratory, Universidade Luterana do Brasil |
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| Brazilian agencies Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Conselho Nacional de Desenvolvimento Científico e Tecnológico, Fundo de Incentivo à Pesquisa e Eventos - Hospital de Clínicas of Porto Alegre |
11-0293 |
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| Corresponding Author |
Francielli Licks, MSc, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS 90040-060, Brazil. francielli.licks@gmail.com.br |
| Key Words |
N-Acetylcysteine; Portal hypertension; Gastropathy; Oxidative stress; Antioxidant |
| Core Tip |
Portal hypertension (PH) is a syndrome with serious manifestations as ascites, hepatic encepha-lopathy and development of collateral circulation, characterized by vasodilation and angiogenesis. This mechanism, intended to divert blood from the site of obstruction, is the leading cause of death among these patients, since it leads to upper gastrointestinal bleeding. Therapies that may contribute to control the development of collateral circulation are been investigated in an attempt to improve the quality of life of PH patients. This paper proposes a novel therapy, using an antioxidant effective in reducing this collateral circulation in an animal model of portal hypertension. |
| Publish Date |
2015-11-18 12:39 |
| Citation |
Licks F, Hartmann RM, Marques C, Schemitt E, Colares JR, Soares MC, Reys J, Fisher C, da Silva J, Marroni NP. N-acetylcysteine modulates angiogenesis and vasodilation in stomach such as DNA damage in blood of portal hypertensive rats. World J Gastroenterol 2015; 21(43): 12351-12360 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i43/12351.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i43.12351 |
