Publication Name	World Journal of Experimental Medicine
Manuscript ID	17858
Country	United States

Received	2015-03-27 08:44
Peer-Review Started	2015-03-28 19:16
To Make the First Decision	2015-05-13 19:47
Return for Revision	2015-05-19 08:52
Revised	2015-06-29 15:57
Second Decision	2015-08-27 12:03
Accepted by Journal Editor-in-Chief	2015-08-28 17:03
Accepted by Company Editor-in-Chief	2015-09-08 15:01
Articles in Press	2015-09-08 15:02
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-11-13 18:30
Publish the Manuscript Online	2015-11-23 08:36

ISSN	2220-315x (online)
Open Access	Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Review
Article Title	Endoplasmic reticulum stress-mediated pathways to both apoptosis and autophagy: Significance for melanoma treatment
Manuscript Source	Invited Manuscript
All Author List	Mohamed Hassan, Denis Selimovic, Matthias Hannig, Youssef Haikel, Robert T Brodell and Mossaad Megahed
Funding Agency and Grant Number
Corresponding Author	Dr. Mohamed Hassan, Cancer Institute, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, United States. dr.hassan@gmx.de
Key Words	Melanoma; Endoplasmic reticulum; Apoptosis; Autophagy; Signaling pathways; Chemotherapy
Core Tip	This editorial describes the clinical validity of the endoplasmic reticulum (ER) as therapeutic target for melanoma treatment. In addition, we highlight in this review the mechanistic role of ER stress in the modulation of both apoptosis and autophagy- associ-ated pathways. Drugs that perturb ER function may represent an alternative approach for melanoma treat-ment. This paper reviews the pervious and current published studies on the reliability of ER-associated pathways as therapeutic targets for melanoma.
Publish Date	2015-11-23 08:36
Citation	Hassan M, Selimovic D, Hannig M, Haikel Y, Brodell RT, Megahed M. Endoplasmic reticulum stress-mediated pathways to both apoptosis and autophagy: Significance for melanoma treatment. World J Exp Med 2015; 5(4): 206-217
URL	http://www.wjgnet.com/2220-315X/full/v5/i4/206.htm
DOI	http://dx.doi.org/10.5493/wjem.v5.i4.206

Full Article (PDF)	WJEM-5-206.pdf
Full Article (Word)	WJEM-5-206.doc
Manuscript File	17858-Review.doc
Answering Reviewers	17858-Answering reviewers.pdf
Audio Core Tip	17858-Audio core tip.wav
Conflict-of-Interest Disclosure Form	17858-Conflict-of-interest statement.pdf
Copyright License Agreement	17858-Copyright assignment.pdf
Peer-review Report	17858-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	17858-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	17858-Scientific misconduct check.pdf
Scientific Editor Work List	17858-Scientific editor work list.pdf