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11/24/2015 3:55:00 PM | Browse: 1093 | Download: 1807
Publication Name World Journal of Gastroenterology
Manuscript ID 17947
Country/Territory United States
Received
2015-03-31 07:56
Peer-Review Started
2015-03-31 11:51
To Make the First Decision
2015-05-18 12:10
Return for Revision
2015-05-20 10:59
Revised
2015-06-02 02:05
Second Decision
2015-07-03 20:56
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2015-07-08 17:27
Articles in Press
2015-07-08 17:27
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-10-27 14:04
Publish the Manuscript Online
2015-11-18 12:39
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Observational Study
Article Title Re-re-treatment of hepatitis C virus: Eight patients who relapsed twice after direct-acting-antiviral drugs
Manuscript Source Unsolicited Manuscript
All Author List Joshua Hartman, Kian Bichoupan, Neal Patel, Sweta Chekuri, Alyson Harty, Douglas Dieterich, Ponni Perumalswami and Andrea D Branch
Funding Agency and Grant Number
Corresponding Author Andrea D Branch, PhD, Division of Liver Disease, Icahn School of Medicine at the Mount Sinai Medical Center, 11th floor, Room 24, 1425 Madison Avenue, New York, NY 10029, United States. andrea.branch@mssm.edu
Key Words Hepatitis C; Protease inhibitor; Relapse; Simeprevir; Sofosbuvir; Treatment failure
Core Tip Direct acting antivirals are revolutionizing the treatment of chronic hepatitis C (HCV) infection, but are also increasing the number of patients who have failed multiple rounds of treatment. Information about these patients is needed to plan salvage treatment strategies. We present eight patients who failed treatment with the first generation protease inhibitors and subsequently failed treatment with simeprevir and sofosbuvir. Their shared characteristics include a history of failed treatment with interferon/ribavirin and liver cirrhosis. Seven had genotype 1a HCV and a high viral load. Our findings suggest that patients with cirrhosis and high viral load remain hard-to-treat.
Publish Date 2015-11-18 12:39
Citation Hartman J, Bichoupan K, Patel N, Chekuri S, Harty A, Dieterich D, Perumalswami P, Branch AD. Re-re-treatment of hepatitis C virus: Eight patients who relapsed twice after direct-acting-antiviral drugs. World J Gastroenterol 2015; 21(43): 12430-12438
URL http://www.wjgnet.com/1007-9327/full/v21/i43/12430.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i43.12430
Full Article (PDF) WJG-21-12430.pdf
Full Article (Word) WJG-21-12430.doc
Manuscript File 17947-Review.docx
Answering Reviewers 17947-Answering reviewers.pdf
Audio Core Tip 17947-Audio core tip.mp3
Biostatistics Review Certificate 17947-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 17947-Conflict-of-interest statement.pdf
Copyright License Agreement 17947-Copyright assignment.pdf
Institutional Review Board Approval Form or Document 17947-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 17947-Language certificate.pdf
Peer-review Report 17947-Peer-review(s).pdf
Scientific Misconduct Check 17947-Scientific misconduct check.pdf
Scientific Editor Work List 17947-Scientific editor work list.pdf