| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Prospective Study |
| Article Title |
Tumor neoangiogenesis detection by confocal laser endomicroscopy and anti-CD105 antibody: Pilot study
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Adriana Ciocâlteu, Adrian Săftoiu, Daniel Pirici, Claudia-Valentina Georgescu, Tatiana Cârţână, Dan Ionuț Gheonea, Lucian Gheorghe Gruionu, Cosmin Gabriel Cristea and Gabriel Gruionu |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Research Council (CNCS), Romania, entitled ‘‘Clinical and Biomathematical Modeling of Vascular Changes Following Anti-Angiogenic Therapy in Advanced Colorectal Carcinoma’’ |
PN-II-ID-PCE-2011-3-0664 |
| European Social Found, Human Resources Development Operational Programme 2007- 2013 |
POSDRU/159/1.5/S/136893 |
|
| Corresponding Author |
Adrian Săftoiu, MD, PhD, MSc, FASGE, Professor, Research Center of Gastroenterology and Hepatology Craiova, University of Medicine and Pharmacy Craiova, Romania, 2 Petru Rares str., Craiova, Dolj 200349, Romania. adriansaftoiu@aim.com |
| Key Words |
Rectal cancer; Neoangiogenesis; Confocal laser endomicroscopy; Panendothelial markers; Anti-CD105 antibody |
| Core Tip |
We evaluated CD105 expression from fresh tissue samples of human rectal adenocarcinoma, using confocal laser endomicroscopy (CLE). While vessels marked with fluorescent CD31 were visible in both normal and malignant tissue, CD105 was predominantly expressed in tumor lesions, having reduced affinity for normal rectal mucosa. Our data showed that CLE using CD105 antibody for tumor vascular network imaging is feasible and that CD105 represents a more specific marker for rectal cancer neoangiogenesis than panendothelial markers. To our knowledge, this is the first study to report the use of fluorescently-labeled CD105 antibody in conjunction with CLE in patients with rectal tumor. |
| Publish Date |
2015-11-17 08:51 |
| Citation |
Ciocâlteu A, Săftoiu A, Pirici D, Georgescu CV, Cârţână T, Gheonea DI, Gruionu LG, Cristea CG, Gruionu G. Tumor neoangiogenesis detection by confocal laser endomicroscopy and anti-CD105 antibody: Pilot study. World J Gastrointest Oncol 2015; 7(11): 361-368 |
| URL |
http://www.wjgnet.com/1948-5204/full/v7/i11/361.htm |
| DOI |
http://dx.doi.org/10.4251/wjgo.v7.i11.361 |
