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Articles Published Processes
12/17/2015 9:04:00 PM | Browse: 795 | Download: 1406
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Received |
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2015-04-10 08:24 |
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Peer-Review Started |
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2015-04-11 23:20 |
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To Make the First Decision |
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2015-06-18 16:10 |
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Return for Revision |
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2015-06-24 14:25 |
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Revised |
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2015-07-09 11:36 |
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Second Decision |
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2015-09-14 10:17 |
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Accepted by Journal Editor-in-Chief |
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2015-09-17 20:17 |
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Accepted by Company Editor-in-Chief |
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2015-10-08 17:41 |
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Articles in Press |
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2015-10-08 17:41 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2015-11-27 19:49 |
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Publish the Manuscript Online |
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2015-12-17 21:04 |
| ISSN |
2218-5836 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Allergy |
| Manuscript Type |
Basic Study |
| Article Title |
Platelet-rich plasma increases transforming growth factor-beta1 expression at graft-host interface following autologous osteochondral transplantation in a rabbit model
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Lorraine A Boakye, Keir A Ross, John M Pinski, Niall A Smyth, Amgad M Haleem, Charles P Hannon, Lisa A Fortier and John G Kennedy |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Arteriocyte Inc. |
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| Ohnell Family Foundation |
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| Mr. and Mrs. Michael J Levitt |
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| Corresponding Author |
John G Kennedy, MD, FRCS, Depart¬ment of Orthopaedic Surgery, Hospital for Special Surgery, 535 East 70th Street, New York, NY 10021, United States. hannonc@hss.edu |
| Key Words |
Platelet rich plasma; Transforming growth factor-beta; Autologous osteochondral transplantation |
| Core Tip |
Despite the prevalence of platelet rich plasma (PRP) in both practice and literature, there is a dearth of data exploring the specific factors crucial to its role as an adjunct to cartilage repair surgeries. Our results suggest that the increased expression pattern of transforming growth factor-beta1 in PRP-treated rabbit femoral condyles, compared to saline treated controls, is associated with enhanced cartilage repair at the graft-host interface following autologous osteochondral transplantation. Our results serve as an initial step in building a body of evidence behind the specific growth factors crucial to cartilage repair and promise to help us understand how formulations of PRP are effective in musculoskeletal healing. |
| Publish Date |
2015-12-17 21:04 |
| Citation |
Boakye LA, Ross KA, Pinski JM, Smyth NA, Haleem AM, Hannon CP, Fortier LA, Kennedy JG. Platelet-rich plasma increases transforming growth factor-beta1 expression at graft-host interface following autologous osteochondral transplantation in a rabbit model. World J Orthop 2015; 6(11): 961-969 |
| URL |
http://www.wjgnet.com/2218-5836/full/v6/i11/961.htm |
| DOI |
http://dx.doi.org/10.5312/wjo.v6.i11.961 |
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