Publication Name	World Journal of Gastroenterology
Manuscript ID	18346
Country	Israel

Received	2015-04-17 15:01
Peer-Review Started	2015-04-19 13:37
To Make the First Decision	2015-06-25 17:38
Return for Revision	2015-06-26 19:25
Revised	2015-07-06 19:38
Second Decision	2015-11-03 18:01
Accepted by Journal Editor-in-Chief	2015-11-04 20:40
Accepted by Company Editor-in-Chief	2015-11-13 17:01
Articles in Press	2015-11-13 17:01
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-12-08 09:42
Publish the Manuscript Online	2016-01-15 14:54

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Role of antibiotics for treatment of inflammatory bowel disease
Manuscript Source	Invited Manuscript
All Author List	Orna Nitzan, Mazen Elias, Avi Peretz and Walid Saliba
Funding Agency and Grant Number
Corresponding Author	Walid Saliba, MD, MPH, Department of Community Medicine and Epidemiology, Carmel Medical Center, 7 Michal St. Haifa 34362, Israel. saliba_wa@clalit.org.il
Key Words	Antibiotic treatment; Inflammatory bowel disease; Ulcerative colitis; Crohn’s disease
Core Tip	The gut microbiota plays an important role in the pathogenesis and complications of inflammatory bowel disease. Antibiotics may influence the course of inflammatory bowel disease by decreasing concentrations of bacteria in the gut lumen and altering the composition of intestinal microbiota. In Crohn’s disease, antibiotics may have a modest effect in decreasing disease activity and achieving remission, are more effective in patients with disease involving the colon, and are useful in the treatment of suppurative complications. Data is more sparse and less conclusive for the treatment of ulcerative colitis, though there might be some benefit in antibiotic treatment. Side effects, the risk of Clostridium dificile infection, and increasing antibiotic resistance should be considered. Further studies are needed to define the role of antibiotic treatment in inflammatory bowel diseases.
Publish Date	2016-01-15 14:54
Citation	Nitzan O, Elias M, Peretz A, Saliba W. Role of antibiotics for treatment of inflammatory bowel disease. World J Gastroenterol 2016; 22(3): 1078-1087
URL	http://www.wjgnet.com/1007-9327/full/v22/i3/1078.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i3.1078

Full Article (PDF)	WJG-22-1078.pdf
Full Article (Word)	WJG-22-1078.doc
Manuscript File	18346-Review.doc
Answering Reviewers	18346-Answering reviewers.pdf
Audio Core Tip	18346-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	18346-Conflict-of-interest statement.pdf
Copyright License Agreement	18346-Copyright assignment.pdf
Peer-review Report	18346-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	18346-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	18346-Scientific misconduct check.pdf
Scientific Editor Work List	18346-Scientific editor work list.pdf