ISSN |
1007-9327 (print) and 2219-2840 (online) |
Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
Website |
http://www.wjgnet.com |
Category |
Gastroenterology & Hepatology |
Manuscript Type |
Case Control Study |
Article Title |
Serum vitamin D3 does not correlate with liver fibrosis in chronic hepatitis C
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Manuscript Source |
Unsolicited Manuscript |
All Author List |
Yan Ren, Mei Liu, Jing Zhao, Feng Ren, Yu Chen, Jun-Feng Li, Jing-Yun Zhang, Feng Qu, Jin-Lan Zhang, Zhong-Ping Duan and Su-Jun Zheng |
Funding Agency and Grant Number |
Funding Agency |
Grant Number |
High technical personnel training item from Beijing Health System |
2011-3-083 |
High technical personnel training item from Beijing Health System |
2013-3-071 |
Beijing Municipal Science & Technology Commission |
Z131107002213019 |
Beijing Municipal Science & Technology Commission |
Z151100004015066 |
Base to Clinical Scientific Research Cooperation fund of Capital Medical University |
15JL67 |
National Science and Technology Key Project on “Major Infectious Diseases such as HIV/AIDS, Viral Hepatitis Prevention and Treatment” |
2012ZX10002004-006 |
National Science and Technology Key Project on “Major Infectious Diseases such as HIV/AIDS, Viral Hepatitis Prevention and Treatment” |
2012ZX10004904-003-001 |
National Science and Technology Key Project on “Major Infectious Diseases such as HIV/AIDS, Viral Hepatitis Prevention and Treatment” |
2013ZX10002002-006 |
Beijing Municipal Administration of Hospitals Clinical medicine Development of special funding support |
XM201308 |
National Key Subject Construction Project |
WJWYA-2014-002 |
Scientific research base construction - the major infectious diseases prevention and control of collaborative innovation center |
115215 |
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Corresponding Author |
Su-Jun Zheng, PhD, MD, Artificial Liver Center, Beijing YouAn Hospital, Capital Medical University, No. 8 Xitou Tiao Road, Youwai Street, Beijing 100069,
China. zhengsujun003@126.com |
Key Words |
Hepatitis C virus; 25-Hydroxyvitamin D3; 24; 25-Dihydroxyvitamin D3; Fibrosis; Inflammation |
Core Tip |
We studied the relationship between liver fibrosis, based on liver biopsies, and serum vitamin D3 levels in Chinese treatment-naive patients with chronic hepatitis C (CHC). The levels of serum 25-hydroxyvitamin D3 [25(OH)D3] were significantly lower in the patients than in healthy control subjects. The levels of the degradation metabolite 24,25-dihydroxyvitamin D3 [24,25(OH)2D3] did not differ between the patients and controls. Spearman’s rank correlation analysis indicated that serum 25(OH)D3 levels did not correlate with the extent of liver fibrosis or inflammation. However, serum 25(OH)D3 levels did correlate with serum 24,25(OH)2D3 levels. Serum 25(OH)D3 and 24,25(OH)2D3 levels, and the 25(OH)D3/24,25(OH)2D3 ratio, have no difference among the fibrosis stages or inflammation grades. In conclusion, the levels of serum 25(OH)D3 and its metabolite 24,25(OH)2D3 did not correlate with liver fibrosis in treatment-naive Chinese patient with CHC. |
Publish Date |
2015-10-19 09:14 |
Citation |
Ren Y, Liu M, Zhao J, Ren F, Chen Y, Li JF, Zhang JY, Qu F, Zhang JL, Duan ZP, Zheng SJ. Serum vitamin D3 does not correlate with liver fibrosis in chronic hepatitis C. World J Gastroenterol 2015; 21(39): 11152-11159 |
URL |
http://www.wjgnet.com/1007-9327/full/v21/i39/11152.htm |
DOI |
http://dx.doi.org/10.3748/wjg.v21.i39.11152 |