BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
12/10/2015 10:17:00 AM | Browse: 585 | Download: 1445
Publication Name World Journal of Gastroenterology
Manuscript ID 18378
Country/Territory China
Received
2015-04-19 10:26
Peer-Review Started
2015-04-20 11:08
To Make the First Decision
2015-06-19 17:55
Return for Revision
2015-06-20 18:12
Revised
2015-07-02 21:28
Second Decision
2015-08-21 13:14
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2015-09-02 15:30
Articles in Press
2015-09-02 15:31
Publication Fee Transferred
Edit the Manuscript by Language Editor
2015-09-15 21:49
Typeset the Manuscript
2015-09-29 17:37
Publish the Manuscript Online
2015-10-19 09:14
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Case Control Study
Article Title Serum vitamin D3 does not correlate with liver fibrosis in chronic hepatitis C
Manuscript Source Unsolicited Manuscript
All Author List Yan Ren, Mei Liu, Jing Zhao, Feng Ren, Yu Chen, Jun-Feng Li, Jing-Yun Zhang, Feng Qu, Jin-Lan Zhang, Zhong-Ping Duan and Su-Jun Zheng
Funding Agency and Grant Number
Funding Agency Grant Number
High technical personnel training item from Beijing Health System 2011-3-083
High technical personnel training item from Beijing Health System 2013-3-071
Beijing Municipal Science & Technology Commission Z131107002213019
Beijing Municipal Science & Technology Commission Z151100004015066
Base to Clinical Scientific Research Cooperation fund of Capital Medical University 15JL67
National Science and Technology Key Project on “Major Infectious Diseases such as HIV/AIDS, Viral Hepatitis Prevention and Treatment” 2012ZX10002004-006
National Science and Technology Key Project on “Major Infectious Diseases such as HIV/AIDS, Viral Hepatitis Prevention and Treatment” 2012ZX10004904-003-001
National Science and Technology Key Project on “Major Infectious Diseases such as HIV/AIDS, Viral Hepatitis Prevention and Treatment” 2013ZX10002002-006
Beijing Municipal Administration of Hospitals Clinical medicine Development of special funding support XM201308
National Key Subject Construction Project WJWYA-2014-002
Scientific research base construction - the major infectious diseases prevention and control of collaborative innovation center 115215
Corresponding Author Su-Jun Zheng, PhD, MD, Artificial Liver Center, Beijing YouAn Hospital, Capital Medical University, No. 8 Xitou Tiao Road, Youwai Street, Beijing 100069, China. zhengsujun003@126.com
Key Words Hepatitis C virus; 25-Hydroxyvitamin D3; 24; 25-Dihydroxyvitamin D3; Fibrosis; Inflammation
Core Tip We studied the relationship between liver fibrosis, based on liver biopsies, and serum vitamin D3 levels in Chinese treatment-naive patients with chronic hepatitis C (CHC). The levels of serum 25-hydroxyvitamin D3 [25(OH)D3] were significantly lower in the patients than in healthy control subjects. The levels of the degradation metabolite 24,25-dihydroxyvitamin D3 [24,25(OH)2D3] did not differ between the patients and controls. Spearman’s rank correlation analysis indicated that serum 25(OH)D3 levels did not correlate with the extent of liver fibrosis or inflammation. However, serum 25(OH)D3 levels did correlate with serum 24,25(OH)2D3 levels. Serum 25(OH)D3 and 24,25(OH)2D3 levels, and the 25(OH)D3/24,25(OH)2D3 ratio, have no difference among the fibrosis stages or inflammation grades. In conclusion, the levels of serum 25(OH)D3 and its metabolite 24,25(OH)2D3 did not correlate with liver fibrosis in treatment-naive Chinese patient with CHC.
Publish Date 2015-10-19 09:14
Citation Ren Y, Liu M, Zhao J, Ren F, Chen Y, Li JF, Zhang JY, Qu F, Zhang JL, Duan ZP, Zheng SJ. Serum vitamin D3 does not correlate with liver fibrosis in chronic hepatitis C. World J Gastroenterol 2015; 21(39): 11152-11159
URL http://www.wjgnet.com/1007-9327/full/v21/i39/11152.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i39.11152
Full Article (PDF) WJG-21-11152.pdf
Full Article (Word) WJG-21-11152.doc
Manuscript File 18378-Review.doc
Answering Reviewers 18378-Answering reviewers.pdf
Audio Core Tip 18378-Audio core tip.m4a
Biostatistics Review Certificate 18378-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 18378-Conflict-of-interest statement.pdf
Copyright License Agreement 18378-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s) 18378-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 18378-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 18378-Language certificate.pdf
Peer-review Report 18378-Peer-review(s).pdf
Scientific Misconduct Check 18378-Scientific misconduct check.pdf
Scientific Editor Work List 18378-Scientific editor work list.pdf