Publication Name	World Journal of Biological Chemistry
Manuscript ID	18404
Country	South Korea

Received	2015-04-20 12:00
Peer-Review Started	2015-04-21 16:01
To Make the First Decision	2015-05-13 19:36
Return for Revision	2015-05-19 15:33
Revised	2015-05-26 12:47
Second Decision	2015-07-14 15:54
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2015-07-23 17:10
Articles in Press	2015-07-23 17:10
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-08-10 17:01
Publish the Manuscript Online	2015-08-26 11:07

ISSN	1949-8454 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Metabolic interplay between glycolysis and mitochondrial oxidation: The reverse Warburg effect and its therapeutic implication
Manuscript Source	Invited Manuscript
All Author List	Minjong Lee and Jung-Hwan Yoon
Funding Agency and Grant Number	Funding Agency Grant Number Basic Science Research Program 20100007381 Liver Research Foundation of Korea
Corresponding Author	Jung-Hwan Yoon, MD, PhD, Professor, Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul 110-799, South Korea. yoonjh@snu.ac.kr
Key Words	Hepatocellular carcinoma; Oxidative stress; Metabolic interventions; Aerobic glycolysis; Lactate
Core Tip	The Warburg effect plays a vital role in cancer cell proliferation and survival, and contributes to the initiation of tumor metastasis. To adapt to rapidly changing microenvironment for survival such as from normoxia to hypoxia, cancer cells vary in metabolic phenotype; “metabolic flexibility”. Even in a hypoxic condition, oxidative cancer cells and/or stromal cells should theoretically exist to support the metabolic fuel for glycolytic cancer cells and handle lactate via the dynamic shuttle; “the reverse Warburg effect”. Treatments against tumor metabolism may aim to target two distinct metabolic pathways of glycolysis and mitochondrial oxidative phosphorylation.
Publish Date	2015-08-26 11:07
Citation	Lee M, Yoon JH. Metabolic interplay between glycolysis and mitochondrial oxidation: The reverse Warburg effect and its therapeutic implication. World J Biol Chem 2015; 6(3): 148-161
URL	http://www.wjgnet.com/1949-8454/full/v6/i3/148.htm
DOI	http://dx.doi.org/10.4331/wjbc.v6.i3.148

Full Article (PDF)	WJBC-6-148.pdf
Full Article (Word)	WJBC-6-148.doc
Manuscript File	18404-Review.docx
Answering Reviewers	18404-Answering reviewers.pdf
Audio Core Tip	18404-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	18404-Conflict-of-interest statement.pdf
Copyright License Agreement	18404-Copyright assignment.pdf
Peer-review Report	18404-Peer-review(s).pdf
Scientific Misconduct Check	18404-Scientific misconduct check.pdf
Scientific Editor Work List	18404-Scientific editor work list.pdf