Publication Name	World Journal of Gastroenterology
Manuscript ID	18437
Country	Japan

Received	2015-04-21 09:30
Peer-Review Started	2015-04-21 16:32
To Make the First Decision	2015-05-18 12:20
Return for Revision	2015-05-22 11:03
Revised	2015-07-11 00:00
Second Decision	2015-08-10 08:21
Accepted by Journal Editor-in-Chief	2015-08-11 15:49
Accepted by Company Editor-in-Chief	2015-08-31 17:24
Articles in Press	2015-08-31 17:24
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-09-11 11:41
Publish the Manuscript Online	2015-09-28 11:42

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Chronic hepatitis C virus infection and lipoprotein metabolism
Manuscript Source	Invited Manuscript
All Author List	Yoshio Aizawa, Nobuyoshi Seki, Tomohisa Nagano and Hiroshi Abe
Funding Agency and Grant Number
Corresponding Author	Yoshio Aizawa, MD, PhD, Professor, Department of Internal Medicine, The Jikei University Katsushika Medical Center, 6-41-2 Aoto, Katsushika-ku, Tokyo 125-8506, Japan. aichanyoshi@yahoo.co.jp
Key Words	Hepatitis C virus; Apolipoprotein; Lipo-viral particle; Dyslipoproteinemia; Lipoprotein
Core Tip	Hepatitis C virus (HCV) and lipids interact closely at multiple stages in the HCV life cycle. HCV infection may have a profound influence on lipid metabolism, while lipids can regulate HCV replication. Infectious HCV forms lipo-viral particles that possess the features of lipoproteins. Examination of lipoprotein sub-fractions and apolipoproteins is inevitable for evaluating the nature of disturbed lipid metabolism. Among apolipoproteins, apolipoprotein E is a key molecule required for HCV entry, and is one of the possible therapeutic targets for interrupting HCV infection. Understanding the disturbed lipid metabolism may shed light on the pathophysiology of HCV infection and help develop novel therapeutics.
Publish Date	2015-09-28 11:42
Citation	Aizawa Y, Seki N, Nagano T, Abe H. Chronic hepatitis C virus infection and lipoprotein metabolism. World J Gastroenterol 2015; 21(36): 10299-10313
URL	http://www.wjgnet.com/1007-9327/full/v21/i36/10299.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i36.10299

Full Article (PDF)	WJG-21-10299.pdf
Full Article (Word)	WJG-21-10299.doc
Manuscript File	18437-Review.docx
Answering Reviewers	18437-Answering reviewers.pdf
Audio Core Tip	18437-Audio core tip.wma
Conflict-of-Interest Disclosure Form	18437-Conflict-of-interest statement.pdf
Copyright License Agreement	18437-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	18437-Language certificate.pdf
Peer-review Report	18437-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	18437-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	18437-Scientific misconduct check.pdf
Scientific Editor Work List	18437-Scientific editor work list.pdf