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Publication Name World Journal of Hepatology
Manuscript ID 1849
Country/Territory Germany
Received
2013-01-10 08:39
Peer-Review Started
2013-01-10 17:23
To Make the First Decision
2013-03-04 11:51
Return for Revision
2013-03-08 11:40
Revised
2013-03-11 21:46
Second Decision
2013-06-19 12:51
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2013-06-20 00:42
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2013-07-15 10:09
Publish the Manuscript Online
2013-07-25 09:10
ISSN 1948-5182 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Autobiography
Article Title Herbalife hepatotoxicity: Evaluation of cases with positive reexposure tests
Manuscript Source Invited Manuscript
All Author List Rolf Teschke, Christian Frenzel, Johannes Schulze, Alexander Schwarzenboeck and Axel Eickhoff
Funding Agency and Grant Number
Corresponding Author Rolf Teschke, Professor, Department of Internal Medicine Ⅱ, Division of Gastroenterology and Hepatology, Klinikum Hanau, Academic Teaching Hospital of the Medical Faculty of the Goethe University of Frankfurt/Main, Leimenstrasse 20, D-63450 Hanau, Germany. rolf.teschke@gmx.de
Key Words Herbalife hepatotoxicity; Herbalife induced liver injury; Herbal hepatotoxicity; Herb induced liver injury; Herbs
Core Tip Our analysis focuses on published cases of suspected Herbalife hepatotoxicity with positive reexposure tests and high causality gradings. Problems included poorly fulfilled test criteria, numerous confounding variables, and the use of liver unspecific, obsolete causality assessment methods. Submitting the case data to well established criteria for positive reexposure tests, the test was positive in 1/8 cases and negative or uninterpretable in the other cases. Using the liver specific Council for International Organizations of Medical Sciences scale, causality was probable in 1 case, unlikely and excluded in the other cases. Thus, causality levels were much lower than hitherto proposed.
Publish Date 2013-07-25 09:10
Citation Teschke R, Frenzel C, Schulze J, Schwarzenboeck A, Eickhoff A. Herbalife hepatotoxicity: Evaluation of cases with positive reexposure tests. World J Hepatol 2013; 5(7): 353-363
URL http://www.wjgnet.com/1948-5182/full/v5/i7/353.htm
DOI http://dx.doi.org/10.4254/wjh.v5.i7.353
Full Article (PDF) WJH-5-353.pdf
Manuscript File 1849-Review.doc
Answering Reviewers 1849-Answering reviewers.pdf
Copyright License Agreement 1849-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 1849-Language certificate.pdf
Peer-review Report 1849-Peer review(s).pdf
Scientific Editor Work List 1849-Scientific editor work list.doc