Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	18704
Country	Italy

Received	2015-04-27 11:10
Peer-Review Started	2015-04-29 11:54
To Make the First Decision	2015-08-31 16:37
Return for Revision	2015-09-01 16:28
Revised	2015-09-15 00:02
Second Decision	2015-12-04 17:21
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-12-14 17:37
Articles in Press	2015-12-14 17:37
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-02-24 19:58
Publish the Manuscript Online	2016-02-27 22:23

ISSN	1948-9366 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Surgery
Manuscript Type	Topic Highlights
Article Title	Laparoscopic complete mesocolic excision with central vascular ligation in right colon cancer: A comprehensive review
Manuscript Source	Invited Manuscript
All Author List	Luca Maria Siani and Gianluca Garulli
Funding Agency and Grant Number
Corresponding Author	Luca Maria Siani, MD, PhD, Minimally Invasive General and Thoracic Surgery Unit, Azienda Unità Sanitaria Locale della Romagna - “Ceccarini Hospital”, Via Frosinone, 1, 47838 Riccione, Italy. lucamaria.siani@gmail.com
Key Words	Right sided colonic cancer; Complete meso­colic excision; Central vascular ligation; Laparoscopy; Quality of surgical specimen; Oncologic outcome
Core Tip	Laparoscopic complete mesocolic excision (CME) with central vascular ligation (CVL) is based on resection of the colon within its intact and inviolate mesocolon with high tie ligation, so to improve the quality of the resection specimen produced; up-to-date anatomo-embryological concepts are analyzed in detail, focusing on the latest studies of the mesenteric organ, its dissection by mesofascial and retrofascial cleavage planes, and questioning the need for a new terminology in colonic resections. The rationale behind the CME with CVL is explained and particular attention is paid to the current surgical techniques. The impact on local recurrence, disease-free and overall survival is reviewed. Current literature about laparoscopic CME with CVL demonstrated better quality of the surgical specimen produced and significant survival advantage when compared to standard non-mesocolic resections, stressing the importance of meso-resectional surgery, especially when performed with minimally invasive techniques: higher surgical quality, faster recovery and better immunological response may in fact contribute to better long term oncologic outcome.
Publish Date	2016-02-27 22:23
Citation	Siani LM, Garulli G. Laparoscopic complete mesocolic excision with central vascular ligation in right colon cancer: A comprehensive review. World J Gastrointest Surg 2016; 8(2): 106-114
URL	http://www.wjgnet.com/1948-9366/full/v8/i2/106.htm
DOI	http://dx.doi.org/10.4240/wjgs.v8.i2.106

Full Article (PDF)	WJGS-8-106.pdf
Full Article (Word)	WJGS-8-106.doc
Manuscript File	18704-Review.doc
Answering Reviewers	18704-Answering reviewers.pdf
Audio Core Tip	18704-Audio core tip.wma
Conflict-of-Interest Disclosure Form	18704-Conflict-of-interest statement.pdf
Copyright License Agreement	18704-Copyright assignment.pdf
Supplementary Material	Supplementary_Material_20150427000920.pdf
Peer-review Report	18704-Peer-review(s).pdf
Scientific Misconduct Check	18704-Scientific misconduct check.pdf
Scientific Editor Work List	18704-Scientific editor work list.pdf