Publication Name	World Journal of Gastroenterology
Manuscript ID	1891
Country	Italy

Received	2013-01-12 21:49
Peer-Review Started	2013-01-13 20:25
To Make the First Decision	2013-02-26 14:46
Return for Revision	2013-02-28 14:52
Revised	2013-03-25 22:08
Second Decision	2013-04-03 15:28
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2013-04-04 04:15
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-05-17 20:35
Publish the Manuscript Online	2013-05-28 09:36

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Colon cancer stem cells: Controversies and perspectives
Manuscript Source	Invited Manuscript
All Author List	Maria Ausiliatrice Puglisi, Valentina Tesori, Wanda Lattanzi, Giovanni Battista Gasbarrini and Antonio Gasbarrini
Funding Agency and Grant Number
Corresponding Author	Maria Ausiliatrice Puglisi, PhD, Department of Internal Medicine and Gastroenterology, Gemelli Hospital, Largo A. Gemelli 8, 00197 Rome, Italy. ausiliapuglisi@yahoo.it
Key Words	Colon cancer stem cells; Colorectal cancer; CD133; Therapy; Chemoresistance
Core Tip	According to the "cancer stem cell" (CSC) theory, tumor growth and spread are driven by a minority of cancer cells which exhibit characteristics similar to normal stem cells. Although CSCs have been implicated in colon carcinogenesis, due to the complexity of their biology and unsolved technical issues, an unequivocally approved identification and isolation strategy is still a matter of debate. Several markers have been used to identify colon CSCs but the function of these proteins in CSC biology has not yet been clarified. Moreover, the possibility that CSCs might contribute to the failure of existing chemotherapies to eradicate malignant tumors, indicate that targeting of CSCs may represent a promising strategy to eradicate chemoresistant cancers. Aim of this review was to acquire more information on the biology of human colon CSCs and shed light on the role of this cells in the onset and the maintenance of colon cancer.
Publish Date	2013-05-28 09:36
Citation	Puglisi MA, Tesori V, Lattanzi W, Gasbarrini GB, Gasbarrini A. Colon cancer stem cells: Controversies and perspectives. World J Gastroenterol 2013; 19(20): 2997-3006
URL	http://www.wjgnet.com/1007-9327/full/v19/i20/2997.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i20.2997

Full Article (PDF)	WJG-19-2997.pdf
Manuscript File	1891-Review.doc
Answering Reviewers	1891-Answering reviewers.doc
Copyright License Agreement	1891-Copyright assignment.pdf
Peer-review Report	1891-Peer review(s).pdf
Scientific Editor Work List	1891-Scientific editor work list.doc