Publication Name	World Journal of Gastroenterology
Manuscript ID	19032
Country	Iran

Received	2015-04-30 10:39
Peer-Review Started	2015-05-06 18:39
To Make the First Decision	2015-06-23 14:58
Return for Revision	2015-06-26 16:46
Revised	2015-07-31 02:59
Second Decision	2015-09-28 16:08
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2015-09-30 10:16
Articles in Press	2015-09-30 10:16
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-10-21 10:03
Publish the Manuscript Online	2015-11-11 13:34

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Nanoscience & Nanotechnology
Manuscript Type	Topic Highlights
Article Title	Nanoparticles for targeted delivery of therapeutics and small interfering RNAs in hepatocellular carcinoma
Manuscript Source	Invited Manuscript
All Author List	Jaleh Varshosaz and Maryam Farzan
Funding Agency and Grant Number
Corresponding Author	Jaleh Varshosaz, Professor, Department of Pharmaceutics, Faculty of Pharmacy and Novel Drug Delivery Systems Research Centre, Isfahan University of Medical Sciences, Isfahan 81745-359, Iran. varshosaz@pharm.mui.ac.ir
Key Words	Small interfering RNA; Targeted delivery; Nanoparticle; Hepatocellular carcinoma; Chemotherapeutic agents
Core Tip	Targeted nanoparticles have gained considerable attention as an efficient drug and gene delivery system in hepatocellular carcinoma owing to their capability for achieving the highest accumulation of cytotoxic agents in tumor tissue, modifiable drug pharmacokinetic- and bio-distribution, improved effectiveness of treatment, and limited side-effects. This review covers a broad spectrum of targeted nanoparticles as therapeutic and non-viral small interfering RNA (siRNA) delivery systems, which are developed for enhanced cellular uptake and targeted gene silencing in vitro and in vivo. Their characteristics and opportunities for the clinical applications of drugs and therapeutic siRNA are discussed in this article.
Publish Date	2015-11-11 13:34
Citation	Varshosaz J, Farzan M. Nanoparticles for targeted delivery of therapeutics and small interfering RNAs in hepatocellular carcinoma. World J Gastroenterol 2015; 21(42): 12022-12041
URL	http://www.wjgnet.com/1007-9327/full/v21/i42/12022.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i42.12022

Full Article (PDF)	WJG-21-12022.pdf
Full Article (Word)	WJG-21-12022.doc
Manuscript File	19032-Review.docx
Answering Reviewers	19032-Answering reviewers.pdf
Audio Core Tip	19032-Audio core tip.wma
Conflict-of-Interest Disclosure Form	19032-Conflict of interest statement.pdf
Copyright License Agreement	19032-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	19032-Language certificate.pdf
Peer-review Report	19032-Peer-review(s).pdf
Scientific Misconduct Check	19032-Scientific misconduct check.pdf
Scientific Editor Work List	19032-Scientific editor work list.pdf